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Possible treatment for kidney disease in lupus

In the U.S. alone, more than 1.5 million people have lupus, a chronic autoimmune disease in which the immune system turns against itself, attacking a person’s healthy tissue, cells and organs. The symptoms can range from debilitating pain and fatigue to organ failure. Dr. Chandra Mohan, a biomedical engineer at the University of Houston (UH), has a theory about the development of lupus nephritis and, if he’s...

Infusions of young blood may reverse effects of ag...

Giving old mice young blood reversed age-related declines in brain function, muscle strength and stamina, researchers say Blood transfusions rejuvenate mice. Could they do the same for humans? Researchers in the US are closing in on a therapy that could reverse harmful ageing processes in the brain, muscles, heart and other organs. Hopes have been raised by three separate reports released by major journals on Sunday that...

Researchers create protein with potential for weig...

It sounds like a magic bullet: Administer a protein, watch the subject lose weight. But that’s exactly what University of Florida scientists found when they discovered a new way to deliver a protein that helps develop cells that convert fat into energy. The study builds upon on a discovery by Bruce Spiegelman, a cell biologist at the Boston-based Dana-Farber Cancer Institute, who found that human muscles release a hormone...

Remarkable Twin Study Widens View of Down’s ...

A large coalition of European and American researchers this week published a new gene expression study of trisomy 21, better known as Down’s syndrome, using a novel cellular model of the disorder. Induced pluripotent stem cells were derived from a set of identical twins, only one of which possessed the third copy of chromosome 21 that causes the symptoms of Down’s syndrome. Because identical twins are genetically...

Gates, Wellcome bet $40M on Kymab’s antibody...

Cambridge, U.K.’s Kymab touts its drug development platform as an ideal way to spotlight new antibodies, and some bright minds would seem to agree, as the Wellcome Trust and Bill and Melinda Gates Foundation have teamed up on a $40 million round for the biotech. Under the Series B terms, each organization will hand over $20 million to support the company’s Kymouse technology, a genetically engineered mouse...

New Protein Finding Gives Hope to Infertility Pati...

Answering the question of “how do babies come in this world” is not easy at any age. You may laugh now, but as children we all heard the stories about some birds and some bees, some storks or other similar versions, while as adults, we are probably telling our children the same tales, so they can find out later, in an academical environment, the truth about conception and birth. But science went even further in trying to...

High protein levels linked to cell death in Parkin...

Researchers may have discovered how a genetic mechanism in a common cause of Parkinson’s works to destroy brain cells in patients–a finding that could help scientists develop new therapies for the devastating disease. Though most causes of Parkinson’s cases are unknown, mutations in a gene called leucine-rich repeat kinase 2–or LRRK2, pronounced “lark two” or “lurk...

Researchers replicate controversial stem cell-clon...

Scientists report that they have replicated a method of growing stem cells from adults using cloning techniques–a discovery that could help propel patient-specific regenerative therapies for a myriad of medical conditions and diseases. Using cells taken from two adult men, investigators from the Research Institute for Stem Cell Research of CHA Health Systems in Los Angeles and Advanced Cell Technology in Marlborough,...

Stabilizing protein complex in brain offers hope f...

A team of investigators has identified a new class of compounds that could work in a specific protein complex in the brain to provide a safe route toward reversing the devastating symptoms of Alzheimer’s. Known as the retromer protein complex, these proteins are found in reduced levels in the brains of Alzheimer’s patients. Retromers play a crucial role in neurons, steering amyloid precursor protein away from a...

The human ‘hairless’ gene identified

It’s not a hair-brained idea: A new research report appearing in the April 2014 issue of The FASEB Journal explains why people with a rare balding condition called “atrichia with papular lesions” lose their hair, and it identifies a strategy for reversing this hair loss. Specifically the report shows for the first time that the “human hairless gene” imparts an essential role in hair biology by...
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