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Stem cells from human body fat used to deliver tre...

Johns Hopkins researchers say they have successfully used stem cells derived from human body fat to deliver biological treatments directly to the brains of mice with the most common and aggressive form of brain tumor, significantly extending their lives. In the mouse experiments, the Johns Hopkins investigators used mesenchymal stem cells (MSCs) – which have an unexplained ability to seek out cancer and other damaged...

NIH lays out plan to work exome data into clinical...

Having seen the cost of exome sequencing tumble in recent years, the National Institutes of Health (NIH) has decided now is the time to jump-start its genomic medicine program. The upshot is more clinical research programs will soon have access to exome sequencing capabilities and NIH support with management of the resulting data. NIH has branded the two-year plan the Clinical Center Genomics Opportunity (CCGO) and committed...

Positing Parkinson’s as an autoimmune diseas...

Parkinson’s disease, like Alzheimer’s disease, is one of the leading neurodegenerative issues being targeted by the biopharmaceutical and life sciences industries today. It is the result of the death of neurons responsible for producing dopamine, which the Parkinson’s Disease Foundation describes as “A chemical messenger that regulates movement by assisting in the effective communication (transmission) of...

UCSF, Stanford and Johns Hopkins join FDA partners...

At a time when Big Pharma is increasingly tapping academic institutions for expertise in informatics and data-driven computer models for drug discovery, the FDA has selected Johns Hopkins University, Stanford University and the University of California, San Francisco (UCSF) for a new initiative aimed at streamlining the drug development and approval process. Under the FDA’s Centers of Excellence in Regulatory Science...

Novavax, U. of Maryland report positive preclinica...

With the arrival of Middle East respiratory syndrome coronavirus in the U.S. and a rising death toll in Saudi Arabia, a vaccine designed by Novavax ($NVAX) and the University of Maryland has shown promise in blocking the infection in animals. In a study published in Vaccine, researchers describe a novel method to rapidly develop vaccines against previously unknown viruses, such as MERS-CoV, which emerge suddenly and cause...

Harvard’s bone marrow-on-a-chip could replac...

Scientists at Harvard’s Wyss Institute for Biologically Inspired Engineering have unveiled their newest tool for drug testing, dubbed “bone marrow-on-a-chip,” the first device of its kind that mimics the structure, functions and cellular make-up of bone marrow. Bone marrow is made up of complex tissue and has, up until now, primarily been studied intact in living animals. Like the Wyss Institute’s...

Canada to set up cancer cloud computing facility

Recognition of the insights hidden in genetic data and the difficulty in extracting them has prompted governments around the world to stump up cash for informatics projects. Canada is set to continue upping its investments in the field, with a cancer cloud computing facility the latest project to secure financial backing. The Natural Sciences and Engineering Research Council initiated the project and has brought Genome...

Possible treatment for kidney disease in lupus

In the U.S. alone, more than 1.5 million people have lupus, a chronic autoimmune disease in which the immune system turns against itself, attacking a person’s healthy tissue, cells and organs. The symptoms can range from debilitating pain and fatigue to organ failure. Dr. Chandra Mohan, a biomedical engineer at the University of Houston (UH), has a theory about the development of lupus nephritis and, if he’s...

Infusions of young blood may reverse effects of ag...

Giving old mice young blood reversed age-related declines in brain function, muscle strength and stamina, researchers say Blood transfusions rejuvenate mice. Could they do the same for humans? Researchers in the US are closing in on a therapy that could reverse harmful ageing processes in the brain, muscles, heart and other organs. Hopes have been raised by three separate reports released by major journals on Sunday that...

Researchers create protein with potential for weig...

It sounds like a magic bullet: Administer a protein, watch the subject lose weight. But that’s exactly what University of Florida scientists found when they discovered a new way to deliver a protein that helps develop cells that convert fat into energy. The study builds upon on a discovery by Bruce Spiegelman, a cell biologist at the Boston-based Dana-Farber Cancer Institute, who found that human muscles release a hormone...
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