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Gossypol Biological Properties

Gossypol:

  • is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
  • is antimalarial being the selective inhibitor of Plasmodium falciparum (pfLDH over hLDHs), an essential enzyme for energy generation within malarial parasite.
  • posesses proapoptotic properties, probably due to the regulation of the Bax and Bcl2.
  • reversibly inhibits Calcineurin and binds to calmodulin.
  • inhibits replication of the HIV-1 virus.
  • an effective protein kinase C inhibitor.

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