Gossypol Biological Properties
Last Updated on Monday, 22 October 2007 11:34 Written by admin Monday, 22 October 2007 11:33
Gossypol:
- is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
- is antimalarial being the selective inhibitor of Plasmodium falciparum (pfLDH over hLDHs), an essential enzyme for energy generation within malarial parasite.
- posesses proapoptotic properties, probably due to the regulation of the Bax and Bcl2.
- reversibly inhibits Calcineurin and binds to calmodulin.
- inhibits replication of the HIV-1 virus.
- an effective protein kinase C inhibitor.
This entry was posted on Monday, October 22nd, 2007 at 11:33 am and is filed under Cancer Research, HIV Research, Medicinal Chemistry, Natural Products, New Products, Reagents, Veterinary Research.
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