Gossypol Biological Properties
Gossypol:
- is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
- is antimalarial being the selective inhibitor of Plasmodium falciparum (pfLDH over hLDHs), an essential enzyme for energy generation within malarial parasite.
- posesses proapoptotic properties, probably due to the regulation of the Bax and Bcl2.
- reversibly inhibits Calcineurin and binds to calmodulin.
- inhibits replication of the HIV-1 virus.
- an effective protein kinase C inhibitor.
