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Molecule could treat a wide range of CNS disorders

Scientists at the Cambridge, MA, startup Sage Therapeutics have discovered an innate mechanism that indirectly influences a key receptor linked to a number of neurologic and psychiatric disorders, including Alzheimer’s, schizophrenia, autism and depression.

The newly discovered natural allosteric modulator influences the N-methyl-D-aspartate (NMDA) receptor, which is known to play a role in regulating synaptic function in the central nervous system and impact human learning, memory and social behaviors.

FierceBiotech