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Validating Assays to Guide Personalized Therapy

med fusion and Theranostics Health are planning to work together to validate the clinical utility of the latter’s TheraLink™ Assays for use as molecular diagnostic aids in therapeutic decision making. The assays are based on measuring the activation status of signal transduction pathways involved in the development and growth of human cancers, to provide oncologists with a molecular map of each tumor’s molecular...

Blocking an Enzyme Boosts Chemotherapy Potency

Partially blocking an oxygen-sensing enzyme known as prolyl hydroxylase domain protein 2 (PHD2) could increase the effectiveness of chemotherapy and help reduce the toxic side effects of treatment on normal tissues, researchers report. PHD2 is an oxygen/redox-sensitive enzyme that induces cellular adaptations to stress conditions. Previous work on tumors by a team at the Vesalius Research Center at the Flanders...

Gene Tied to Emergence of Chemotherapy Resistance

Researchers say analyzing a particular gene in high-grade serous cancer (HGSC) could help predict whether a patient’s tumor is likely to become resistant to chemotherapy over time. A team headed by researchers at the Peter MacCallum Cancer Center in Melbourne, Australia, has found that the emergence of treatment resistance in HGSC is associated with a loss or downregulation of the lipid transporter LRPB1 in the tumor. ...

AstraZeneca Partners on miRNA Inhibitors

AstraZeneca is paying Regulus Therapeutics $28 million up front as part of a strategic alliance focused on the discovery and development of microRNA therapeutics against three specified targets in the fields of cardiovascular metabolic diseases and oncology. The payment from AstraZeneca will be made in the form of an equity investment and up front cash. Under terms of the deal Regulus will lead preclinical development,...

Firms Flock to Epic’s CTC Platform

Cancer diagnostics specialist Epic Sciences reported signing collaborations with six pharma companies centered on the application of its circulating tumor cell (CTC) capture and analysis technology to identify biomarkers that can serve as the basis of companion diagnostics. The collaborations involve 12 clinical trials that are part of 40 distinct projects measuring 18 different markers. Epic was spun out of the...

FDA Approves Tudorza Pressair for COPD

The FDA on Monday approved Tudorza™ Pressair™ (aclidinium bromide inhalation powder) for long-term maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. Forest Laboratories is distributing the drug in the U.S. under a license with Barcelona, Spain-based Almirall; the two companies co-developed the drug. Tudorza is...
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