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Epigenetic mechanisms in bone

Abstract Epigenetics refers to the study of mechanisms able to influence gene expression in a stable and potentially heritable manner without altering the DNA sequence. These mechanisms include posttranslational histone modifications, miRNA-mediated post-transcriptional regulation and DNA methylation. The accumulation of molecular errors over time resulting, at least partly, in the alteration of normal epigenetic patterns is...

NIH announces $100M for new HIV research initiativ...

The Obama administration announced Monday afternoon that the National Institutes of Health will redirect $100 million in funding to establish a new, three-year program to find better treatments–and eventually, a cure–for HIV and AIDS. Dubbed the HIV Cure Initiative, the new investment is meant to spark basic research in this area, which is expected to benefit AIDS research in general, as well as research on other...

Royal Society of Chemistry announces a new reposit...

The Royal Society of Chemistry announces a new subject-based repository that will make it easier for researchers to find and share relevant journal articles and data from a single point of access. David James, the Royal Society of Chemistry’s Executive Director of Strategic Innovation, said: “The Chemical Sciences Repository will offer free-to-access chemistry publications and integrated data in a single...

Trio of New York biomedical institutions join forc...

Memorial Sloan-Kettering Cancer Center, The Rockefeller University and Weill Cornell Medical College announced today that they have formed the pioneering Tri-Institutional Therapeutics Discovery Institute, Inc. (Tri-I TDI) and have partnered with Takeda Pharmaceutical Company, Ltd. This new, groundbreaking institute, designed to expedite early-stage drug discovery into innovative treatments and therapies for patients, was...

Ancient Medical Texts to Help Drug Development

In 2002, Alain Touwaide came across an article about the discovery, some years before, of a medical kit salvaged from a 2,000-year-old shipwreck off the coast of Tuscany. Divers had brought up a copper bleeding cup, a surgical hook, a mortar, vials and tin containers. Miraculously, inside one of the tins, still dry and intact, were several tablets, gray-green in color and about the size of a quarter. Touwaide, a science...

Rare disease dictionary

While bioinformatics lies at the leading edge of biological research, it is still underpinned by one of the oldest tools available to humanity: communication. Recognizing this, researchers are trying to standardize terminology through the creation of a rare genetic disease dictionary. The project stemmed from rising awareness that while lots of researchers are working to identify rare diseases and their related genes, their...
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