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Illuminate key structure in heart cells

After a decade of debate, scientists have a clear picture of a controversial protein that helps regulate heart contractions. Brandeis University researchers have unlocked a controversial structure in heart cells responsible for regulating heart contractions. For years, scientists have debated how many KCNE1 proteins are required to build a potassium ion channel, theorizing anywhere between one and 14. Now, Brandeis University...

Epilepsy drug reverses fatty liver disease in obes...

A commonly used epilepsy drug may be able to stop fatty liver disease and prevent Type 2 diabetes in obese people, according to a new study by Johns Hopkins researchers. Scientists found that valproic acid, an anticonvulsant and mood-stabilizing drug prescribed to epilepsy patients, reduced fat accumulation in the liver and lowered blood sugar levels in obese mice. Obesity and a high-fat diet is often associated with the...

Cubist’s superbug drug clears FDA panel

Cubist’s latest antibiotic won praise from a panel of FDA advisers, setting the stage for a likely approval and head-to-head competition with Pfizer’s blockbuster Zyvox. The FDA’s Anti-Infective Drugs Advisory Committee voted 14-0 to recommend approval for Cubist’s tedizolid phosphate to treat acute bacterial skin infections, which are caused by drug-resistant pathogens including MRSA. The drug can be...

Prion discovery helps keep deadly brain diseases i...

New research from David Westaway, PhD, of the University of Alberta and Jiri Safar, PhD, Case Western Reserve University School of Medicine has uncovered a quality control mechanism in brain cells that may help keep deadly neurological diseases in check for months or years. The findings, published in The Journal of Clinical Investigation, “present a breakthrough in understanding the secret life of prion molecules in the...

Mushroom-derived compound could stamp out HPV infe...

A compound derived from mushrooms may provide a new therapeutic option for treating human papillomavirus and curbing HPV-related cancers. Researchers at the University of Texas Health Science Center Medical School at Houston treated HPV-positive mice with active hexose correlated compound, or AHCC, a natural supplement produced from the shiitake mushroom family, and found that a once-daily treatment of the compound began to...

Radiation able to be securely stored in nontoxic m...

Researchers have discovered that microscopic “bubbles” developed at Kansas State University are safe and effective storage lockers for harmful isotopes that emit ionizing radiation for treating tumors. The findings can benefit patient health and advance radiation therapy used to treat cancer and other diseases, said John M. Tomich, a professor of biochemistry and molecular biophysics who is affiliated with the...
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