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Horizon Applies Gene Editing to Huntington’s Disea...

Horizon Discovery inked a gene-editing research collaboration with the Institute of Neurology, University College London. The partnership will focus on the creation of human isogenic disease model cell lines with insertion of Huntington’s disease-causing triplet repeats. The company will provide UCL with access to GENESIS, its rAAV-mediated human gene-editing platform. This collaboration is a novel one for Horizon:...

GE Healthcare, BGI Explore Stem Cell Genetics with...

GE Healthcare and China-based sequencing firm BGI signed a multiyear stem cell science collaboration that aims to provide new insights into the genetic variation of ethinically diverse human stem cell lines. The ultimate goal is to enable the development of relevant human stem cell assays for use in drug discovery and toxicity. Two projects will initially be undertaken. In the first BGI will carry out genome sequencing...

Prosolia, AB Sciex Obtain License for ORNL Analyti...

Prosolia and AB Sciex entered into a license agreement for technologies developed by Gary Van Berkel, Ph.D., and his colleagues at Oak Ridge National Laboratory (ORNL). The arrangement provides Prosolia a license to a portfolio of new sample introduction and ionization methods based on the liquid microjunction surface sampling probe approach that enables direct extraction of solid-phase analytes from a variety of surfaces...

GE Healthcare, Karolinska University Ally to Enabl...

GE Healthcare Life Sciences and Karolinska University Hospital established a collaboration to develop the technologies and workflows that will be needed to apply cell therapies routinely in a clinical setting. The goal is to address the need for reproducible technologies in areas such as cell growth, handling, processing, and analysis as well as protocols and workflows for manufacturing and quality control. The...

MSC-Secreted Factor Key to Impact of Multiple Scle...

Scientists have identified a factor in the conditioned medium of mesenchymal stem cell (MSCs) cultures that appears to play a key role in the therapeutic effects of MSC-based therapy in multiple sclerosis (MS). Studies by Case Western Reserve University researchers in the experimental autoimmune encephalomyelitis (EAE) mouse model of MS demonstrated that treatment using conditioned medium from cultured human MSCs...

Osiris Wins Race to Market a Stem Cell Product wit...

Osiris Therapeutics’ adult stem cell therapy Prochymal® received approval from Health Canada for the treatment of acute graft-vs-host disease (GvHD) in children who failed to respond to steroids. The company will have to carry out certain post-launch confirmatory studies. The decision gives Osiris the distinction of being the first company to win full marketing approval of a stem cell product. Prochymal is an...
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