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Toward Drug Repurposing in Epigenetics

DNA hypomethylating drugs that act on DNA methyltransferase (DNMT) isoforms are promising anticancer agents. By using a well-characterized live-cell system to measure DNA methylation revisions (imprints), we characterize olsalazine, an approved anti-inflammatory drug, as a novel DNA hypomethylating agent. The cell-based screen used in this work is highly tractable, internally controlled, and well-suited for a drug repurposing...

Sony teams with Illumina working on Japanese genom...

Sony has struggled financially in recent years, with its shrinking share of the TV market and a sector-wide slump in PC sales dragging the company down. With the electronics business floundering, management is looking to other sectors to prop up the business and thinks it has found the next growth engine–genomics. The Japanese business ($SNE) is entering the sector by setting up a company called P5. It’s...

The Human Protein Atlas

SciLifeLab have announced that The Human Protein Atlas project has reached a major milestone by releasing protein data for more than 80% of the human protein-coding genes and RNA expression data for more than 90% of the genes. The Protein Atlas has also been restructured into 4 sub-atlases, of which the largest, The Normal Tissue Atlas, now provides the first comprehensive distribution map of both protein and gene expression...

Epigenetics enigma resolved

Scientists have obtained the first detailed molecular structure of a member of the Tet family of enzymes. The finding is important for the field of epigenetics because Tet enzymes chemically modify DNA, changing signposts that tell the cell’s machinery “this gene is shut off” into other signs that say “ready for a change.” Tet enzymes’ roles have come to light only in the last five years;...

Major Update to the Human Reference Genome

The Genome Reference Consortium (GRC), the research collaborative responsible for maintaining a comprehensive reference genome for humans, mice, and zebrafish, has released its first complete update to the human reference genome in nearly half a decade. Reference genomes are crucial to genomic research, providing a baseline for assembling genetic fragments into a full picture of the genome, and comparing rare variants against...

Horizon in gene editing alliance

Cambridge personalised medicines pioneer Horizon Discovery is developing gene editing technology recently licensed from Harvard in a collaboration with UK startup Desktop Genetics. Horizon CEO, Dr Darrin Disley invested in the young business in an August funding round. Horizon and Desktop Genetics have now joined forces to develop a CRISPR design platform. This will be used by Horizon to quickly identify the best guide-RNAs...
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