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FDA Sanctions Roche’s CMV Test

Roche’s Cobas® AmpliPrep/Cobas TaqMan® CMV test for evaluating cytomegalovirus (CMV) load received FDA premarket approval. The firm says the fully automated assay is the first FDA-approved laboratory test for use in quantifying CMV DNA in human plasma specimens. The assay is designed to aid in the management of solid organ transplant patients undergoing anti-CMV therapy by assessing virologic response to therapy. The...

nanoMR, Stratos Partner on Pathogen Detection

Stratos Product Development is teaming up with pathogen detection firm nanoMR to develop instrumentation for the latter’s Pathogen Capture System (PCS). The platform uses an immunomagnetic capture process to isolate rare cell types including bacterial and fungal pathogens directly from blood or other samples for further phenotypic or molecular analysis. The system can target multiple cell types simultaneously, or...

Marina, Girindus Ink Oligonucleotide Manufacturing...

Girindus has obtained the exclusive rights to develop, supply, and commercialize certain oligonucleotide constructs using Marina Biotech’s conformationally restricted nucleotide (CRN) chemistry. In return Marina will receive royalties from the sale of CRN-based oligonucleotide reagents as well as a robust supply of cGMP material for Marina and its partners’ preclinical, clinical, and commercialization...

Admescope to Provide PlexPress Multiplex CYP Gene ...

CRO Admescope will offer PlexPress’ TRAC (transcript analysis with the aid of affinity capture) platform for high-throughput gene expression analysis as part of its in vitro drug interaction and preclinical ADME-Tox services. Finland-based Admescope will initially offer Plexpress’ multiplex cytochrome P450 (CYP) assays. The firm says the service will meet FDA’s recent draft recommendations that cytochrome P450...

Curetis Wins CE Mark for POC Diagnostic Platform, ...

Molecular diagnostics firm Curetis announced the award of a CE mark for its Unyvero™ point of care diagnostic platform and the first disposable cartridge-based test for the system, P50 Pneumonia. The automated assay is designed to simultaneously test for 39 DNA targets from a range of pneumonia-causing bacteria and determine antibiotic resistance. The Unyvero system allows the fully automated DNA-based testing...

X-Ray Crystallography Identifies New Target Domain...

A detailed study of the crystal structure of Poly(ADP-ribose) polymerase-1 (PARP-1) complexed with a double-stranded DNA break has identified specific domains on the enzyme that could represent targets for the design of more specific PARP-1 inhibitors. PARP-1 is a protein that detects and responds to DNA breaks, and inhibitors targeting the enzyme are being tested in anticancer trials. PARP-1 inhibitors...
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