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Cancer Research UK will repurpose an AstraZeneca a...

Cancer Research UK has struck a deal with AstraZeneca ($AZN) to repurpose an experimental therapy originally developed by the drug giant for asthma and study its ability to fight kidney cancer. Under the agreement, the nonprofit’s drug development office will carry out preclinical testing and early clinical trials of the compound, AZD2098. Cancer Research UK plans to begin enrolling up to 40 patients in an early phase...

Human, animal or plant mixed in new R&D recip...

Can a crop science team of ag-bio investigators provide some real insights that could help advance new drugs for humans and animals? Bayer believes so, and one of its top researchers says you can expect to see the first tangible fruits of its hybrid R&D effort in the next few years. Wolfgang Plischke, the outgoing tech/innovation chief at Bayer, told Reuters that “we expect it to be reflected in our pipeline in the...

Two-Layer Screen Locates Both Drugs and Targets

Scripps researchers are exploring a new screening method that combines a phenotype-based screen for compounds with a desired cellular effect, and a target-based screen to determine which molecular pathways are being affected. Rather than a purely phenotypic model, which often reveals promising drugs but does not reveal why they work, or a purely target-based model, which may exclude effective compounds because they do not hit...

Multitarget paradigm in drug discovery

Increasing evidence that several drug compounds exert their effects through interactions with multiple targets is boosting the development of research fields that challenge the data reductionism approach. In this article, we review and discuss the concepts of drug repurposing, polypharmacology, chemogenomics, phenotypic screening and high-throughput in vivo testing of mixture-based libraries in an integrated manner. These...

Rapid vaccine development against deadly diseases

Scientists from the Uniformed Services University of the Health Sciences (USU) have developed a new preparation method that renders a virus or bacterium non-infectious while preserving its immune-boosting ability after exposure to gamma radiation. A lethally irradiated vaccine was successfully tested in mice against drug-resistant Staphylococcus aureus bacteria by colleagues at the National Institutes of Health (NIH), and...

Male contraceptive breakthrough

Detailed in the Dec. 2 issue of the Proceedings of the National Academy of Sciences, a team at the Monash Institute of Pharmaceutical Sciences in Australia, in collaboration with researchers from the University of Melbourne and University of Leicester in the U.K., has figured out a way to block the transport of sperm during ejaculation by blocking two key proteins. In a mouse model, investigators found the absence of these...
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