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New Pig Models for Cancer Studies

A naturally occurring line of immunodeficient pigs can support the growth of human tumors injected under their skin, offering a promising new large-animal model for studying human cancers and testing new drugs and treatment strategies. The ability of human melanoma cells and pancreatic carcinoma cells to grow in these pig models is described in an article in BioResearch Open Access, a new bimonthly peer-reviewed open...

OGT Awarded $3.6M for Next-Generation Sequencing

Oxford Gene Technology (OGT) next-generation sequencing service team has been awarded two EU-funded clinical research grants worth €3 million (approximately $3.6 million). OGT will be providing genomic analysis and commercialization services for two international studies, EUCLIDS and PATHSEEK. EUCLIDS (EU Life-threatening Infectious Disease Study), is a five-year, large-scale study to identify genomic variants that...

Harrington Project Establishes BioMotiv Commercial...

A translational medicine investment company, BioMotiv, has been established as part of the $250 million Harrington Project for Discovery and Development initiative announced by University Hospitals in February. BioMotiv aims to raise initial capital of $100 million as it builds a portfolio of technologies in-licensed from academic medical centers associated with The Harrington Project and other sources. Operating as...

Drug Safety Executive Council™ to Participate in 8...

Dr. Ernie Bush, Vice President of Collaborative Projects for DSEC, speaks on industry trends in predictive toxicology The Drug Safety Executive Council™ (DSEC™) is pleased to announce that Dr. Ernie Bush, Director of Collaborative Projects, is a featured speaker at the 8th North American Drug Discovery Workshop, co-sponsored by Cyprotex. Dr. Bush’s presentation is entitled Industry Trends in Predictive Toxicology...

Sanford-Burnham robots speed up path to discovery

The work force at Lake Nona’s Sanford- Burnham Institute includes 90 scientific staffers, 60 administrators and support personnel — and a team of three robots. The robots are part of a $15 million investment from the National Institutes of Health and occupy a large, glass-enclosed room on the bottom floor of Burnham’s Lake Nona campus. Although they resemble the robotic arms used in automobile assembly...

Formulation strategies for improving drug solubili...

Abstract: The solubility behavior of drugs remains one of the most challenging aspects in formulation development. Solid dispersions have been employed to enhance the dissolution rates of poorly water – soluble drugs. This article reports various solubility enhancement strategies in solid dispersion. The approaches described are fusion (melting), solvent evaporation, lyophilization (freeze drying), melt...
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