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Gilson Introduces the Pipetman Concept® 8×300 and 12×300 Electronic Multichannel Pipettes

Last Updated on Friday, 10 February 2006 07:22 Written by admin Friday, 10 February 2006 07:22

Gilson announces the release of the Pipetman Concept® 8×300 and 12×300 electronic multichannel pipettes. The Pipetman Concept® x300 is an exceptional combination of quality with high usability and comfort. This product launch marks the first multichannel pipettes to be released from the Pipetman Concept product line.

The patented, multifunction thumbwheel ensures a fast and convenient way to set the volume, navigate and select menu options. In addition to its distinctive Pipetting features, the Pipetman Concept® x300 incorporates a one-of-a-kind connection to your PC via USB port. The Utility Software gives the users the ability to create custom operating modes on his or her computer, and transfer them to the pipette; a great feature to speed up today’s complex Pipetting tasks. The Utility Software also allows the user to check and modify the pipette parameters in addition to creating maintenance reports.

The ergonomic design of the body handle addresses users’ concern for Repetitive Strain Injuries while the exclusive Gilson Forceless Integrated Tip Ejection System™ (G-F.I.T.) provides instant, reliable seals with low tip ejection forces. The G-F.I.T. System is based on a special stepped design of the tip-holders as apposed to the conventional conical design. Fitting a tip produces two small contact areas between the tip-holders and the tips. The first ridge creates a ring-shaped contact area that focuses the seal force on a very small area, and in turn, provides an efficient air-tight seal. The second works as a guide and a stop to prevent over-insertion of the tip-holder into the tip. The G-F.I.T. System is compatible with most standard tips.

The Pipetman Concept multichannel x300 is available in 8- and 12-channel models, and covers a volume range of 20µL to 300µL.

Gilson®, Inc., a leader in preparative HPLC, manufactures high-quality dependable liquid chromatography and automated liquid handling instruments to meet the needs of today’s scientist. Product lines include a full range of HPLC systems – from nano to preparative – as well as high-throughput robotic workstations and software solutions. For More information about Gilson, Inc. products or services, visit www.gilson.com.

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Microplate Instrument Trends

Last Updated on Thursday, 15 December 2005 02:41 Written by admin Thursday, 15 December 2005 02:41

This market report summarizes the results of a comprehensive global Pharma/Biotech web-based survey on microplate instrumentation trends carried out in May 2005. The main survey looked at the factors that currently limit productivity from a microplate instrumentation perspective; current and future use of microplate detection instruments and microplate readouts; liquid handling for bulk reagent dispensing and sample addition; difficulty in enabling liquid handling applications and reliability of dispensing; current and future use of microplate washers and washing applications; comparative vendor use and respondent ratings; use of different microplate formats and total assay volumes; data point metrics; and microplate instrument budgets and breakdown.

Purchase report >>

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Nanion Technologies GmbH

Last Updated on Monday, 10 October 2005 12:05 Written by admin Monday, 10 October 2005 12:05

Nanion achieves outstanding rank for overall instrument performance in a recent ion channel survey by HTStec focused on real user experience of automated patch clamping (“HTStec Ion Channel Trends 2005″)!

In September 2005, HTStec has published a new ion channel survey focused on user experience of automated patch clamping. The objective of this global benchmarking study is to comprehensively document current practices and technology preferences, progress in implementing high throughput electrophysiology (automated patch clamping) and future trends in ion channel screening.
One of the key outcomes of this survey, is the overwhelming success of Nanions Port-a-Patch: more than 80% of the Port-a-Patch users are very happy with overall instrument performance! This is by far the best rank compared to other instrument providers. The statistics are shown in the table below. The complete results of the survey called “HTStec Ion Channel Trends 2005″ can be obtained via www.htstec.com.

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TrueTaperâ„¢ 96 -Well Collection Plate from Analytical Sales & Products, Inc.

Last Updated on Thursday, 6 October 2005 02:50 Written by admin Thursday, 6 October 2005 02:50

TrueTaper™ 96 -Well Collection Plate has been designed for chromatographers who are faced with limited sample quantity. TrueTaper™ incorporates a smooth, tapered well shape which allows the entire sample to gravitate to the bottom of the well. The total volume is 2mL, however, we have stretched and tapered the bottom of the well to hold a capacity of 100µL which enables full access of your sample for extraction.

http://www.analytical-sales.com

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Automation server streamlines cell-based screening

Last Updated on Friday, 16 September 2005 11:42 Written by admin Friday, 16 September 2005 11:42

Software enables a personal cell analysis system to become a true walk-away cell-based screening system, intelligently automating hours of microplate processing with no user invention.

uavaLink Automation Server software has been developed to automate the processing of multiple microplates on Guava Personal Cell Analysis (PCA) systems. Intuitive in operation, the ultra-compact Guava PCA-96 and Easycyte systems are said to have set an international benchmark for single cell analysis and counting in the 96-well format. GuavaLink allows robot scheduling software to control and integrate Guava PCA systems with all physically compatible robotic arms and Liquid Handling systems – the result streamlined workflow and enhanced productivity.

Using a series of user-defined worklists, the robot scheduling software is able to send commands to the system while instructing the robotic arm to move microplates to and from a Guava PCA system.

This flexible worklist system allows users to interchange and process different cell-based assays within a microplate series.

GuavaLink enables a Guava PCA system to become a true walk-away cell-based screening system, intelligently automating hours of microplate processing with no user invention.

The Guava EasyCyte is a five-parameter system microplate cytometer microplate cytometer that is flexible, highly affordable, and ultra-compact.

Since it requires only a few microlitres of sample volume, it saves precious and expensive cells, reagents, and compounds.

The system is so easy to use, results are generated with less than a day’s training.

The Guava PCA-96 offers turnkey operation in an integrated system consisting of the compact Guava PCA-96 instrument, software to automatically analyse and archive data, and optimised reagents.

The Guava PCA-96 system simplifies cell monitoring and screening, only a few microlitres of samples are required for each experiment, saving precious cells and reagents and reducing potentially hazardous biological waste.

With the Guava PCA-96 experiments can be started sooner and finished faster streamlining the entire research and development process, the company says.

Current screening assays available for the Guava PCA-96 and Easycyte systems include cell counting and viability, cell marker expression, cytotoxicity, cell cycle, CD4/CD8 absolute counting and a suite of assays for apoptosis assessment and cell tracking.

Guava Technologies, a privately held biotechnology and Medical Device company, is a provider of on-demand, easy-to-use single cell analysis systems.

Guava Personal Cell Analysis (PCA) systems, including the Guava PCA, Guava PCA-96 and Guava EasyCyte systems, are described as integrated, fully optimised, micro-capillary cytometry systems with embedded absolute cell counting capability.

Used worldwide by the life sciences, biotechnology, and pharmaceutical industries, as well as clinical testing institutions (outside the United States and Europe), Guava’s products have broad applications in scientific research and throughout the drug discovery and lead optimisation process, as well as for cell counting and optimisation of commercial bio-pharmaceutical production.

Guava offers a variety of assays and dedicated software modules for the Guava PCA systems, enhancing the system’s overall ease-of-use.

Posted under ChemInformatics, Equipment & Supplies, New Products, North America  |  Comments Off

TTP LABTECH SUPPLY SIENABIOTECH SPA WITH COMPOUND STORAGE CAPABILITY

Last Updated on Thursday, 14 July 2005 04:46 Written by admin Thursday, 14 July 2005 04:46

TTP LabTech will be supplying Sienabiotech SpA with compound storage capability based on the comPOUND storage system. The deal involves a comPOUND sample store and a comPILER store-to-plate preparation system.

The new comPOUND system will be used by Sienabiotech in drug discovery programmes to facilitate storage, handling and registration required for hit validation and the identification of lead molecules relevant for treatment of neuronal diseases.

“The implementation of TTP LabTech’s compound storage system is an important step for Sienabiotech S.p.A. enabling integration of our compound collection and compound screening strategies”,- said Dr. Graeme Robertson, Vice President Therapeutic Research, Sienabiotech S.p.A. – “the flexibility of the system will allow us the desired sample storage and sample selection protocols to match compound selection to the targets being screened”.

TTP LabTech’s comPOUND is a self-contained, modular microtube storage system. Each comPOUND module can store up to 200,000 microtubes in a dry and inert environment at -20°C. Multiple comPOUND modules may be linked to provide expandable library storage capacity. comPILER is a modular store-to-plate processing system which assembles racks of selected microtubes received from comPOUND, and can process more than 15,000 microtubes in an 8-hour day without operator intervention. comPILER has been tailored to suit Sienabiotech’s requirements.

About Sienabiotech SpA
Sienabiotech is an innovative drug discovery company located in Siena, Italy. The company’s focus is on diseases of the central nervous system, including rare diseases, with the aim of pursuing validated drug targets and lead molecules for therapeutic intervention. In order to support the drug discovery process from exploratory target identification towards clinical studies, the company applies the most advance technologies in the field. Sienabiotech is the instrumental company owned by the Monte dei Paschi di Siena Foundation for Scientific and Biotechnological Research.

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Thermo Electron Corp.

Last Updated on Monday, 13 June 2005 05:02 Written by admin Monday, 13 June 2005 05:02

Patricia Henson, Raman Product Manager
In order to better understand solid state compounds that are candidates for new drugs, pharmaceutical companies are employing new technologies in the screening of hundreds of compounds on a daily basis. An important factor in solid state drug forms is polymorphism—a solid-state phenomenon whereby an element or compound can exist in more than one crystalline form.

Polymorphs affect pharmacologically relevant properties, such as bioavailability, dissolution and stability, drug manufacturability and processing, and are used to legally define a compound as a unique, patentable composition. Therefore, pharmaceutical companies are under considerable pressure perform exhaustive compound screening to identify and protect all possible forms early in the drug discovery and development process.

Raman spectroscopy has long been regarded as an excellent technique for identifying polymorphs, however until recently, set-up, calibration and maintenance of the instrument excluded it from high throughput applications. Developments in modern Raman instrumentation, starting with the use of laser and then the introduction of sensitive charge-coupled device (CCD) cameras, high-throughput filters, and improved software have made Raman a useful tool for many types of routine analysis.

Because samples require no special handling, and precise stage automation and the ability to sample 96-well plates, Raman spectroscopy is poised to be a workhorse technique in high throughput crystallization studies.

While data collection has been streamlined to handling hundreds of well containing various chemical mixtures, analyzing the hundreds of spectra collected each hour becomes the new bottleneck. Thermo Electron Corporation has developed new software algorithms that not only facilitate high throughput data collection, but also present clearly understood analytical results by rapidly grouping known and unknown crystalline forms. Early adopters report that processes that would have required hours of manual spectra-by-spectra analysis can now be done automatically in a matter of minutes.

Thermo Electron Corp.
Thermo Electron
eBusiness
81 Wyman Street
Waltham, MA, 02454-9046

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Lab901: it’s in the box

Last Updated on Friday, 3 June 2005 02:09 Written by admin Friday, 3 June 2005 02:09

Rising Scottish technology company, Lab901 has shipped the first of its pioneering ScreenTape systems, only days after receiving a crucial £1 million in third-round equity funding, led by Archangel Informal Investments. The first ScreenTape system has been delivered to the Scottish Centre for Genomic Technology and Informatics (SCGTI) at the University of Edinburgh. This significant milestone and latest cash injection will act as a catalyst for the full commercialisation of ScreenTape, which begins a programme of live evaluations in labs across the UK – including an existing co-development project with pharmaceutical giant, GlaxoSmithKline – and has led to an expansion of Lab901’s team and facilities. It also marks the beginning of a step-change in analytical testing for the multi-billion pound global life-sciences market, as processing times are slashed and labour-intensive scientific instruments are shrunk into a box the size of a desktop printer.

The ScreenTape system comprises a consumable plastic strip, onto which several liquid samples may be loaded simultaneously, together with a self-contained testing and analysis instrument. Reactions occurring on the tape are captured within the instrument and analysed by specialised software, enabling rapid and automated analysis of minute volumes of samples, such as DNA.

John Beattie, COO at SCGTI, said: “We are impressed by the results of the initial trials. ScreenTape reduces the time it takes us to perform key analysis of DNA and RNA molecules from hours to minutes. The automated system means that our scientists are freed up to get on with the more thoughtful and valuable aspects of their research. ScreenTape represents a really exciting development for us.”

Joel Fearnley, CEO of Lab901, said: “After three years of perfecting the science and engineering behind ScreenTape, it is extremely gratifying to receive this vote of confidence from our financial backers and, more importantly, our first customer. Lab901’s multidisciplinary approach incorporates in-house biochemists and polymer experts with mechanical, electrical and software engineers who, together, have created an innovative product with a huge market opportunity. Our priority now is to use the momentum of this ongoing development to drive commercial success and achieve our revenue target of £20 million within four years.”

Key to this strategy is the appointment of Graham Miller as non-executive director for business development, along with plans to develop a highly specialised and experienced sales and marketing team. Miller, previously a vice-president of business development at Smith’s Detection, is a seasoned dealmaker who will be instrumental in Lab901’s current advanced discussions with potential international route-to-market partners.

The latest £1 million tranche of funding was led by long-time backers Archangel Informal Investments, joined by the Scottish Enterprise Co-Investment Fund, Ashleybank and TriCapital.

Peter Shakeshaft, CEO of Archangel Informal Investments, added: “Lab901 has proven time and time again its ability not only to innovate, but also to meet ambitious commercial goals, including doubling the size of its team and premises and, now, winning its first customer. With the appointment of Graham Miller and the escalation of its sales and marketing activities, Lab901 is well positioned for the next phase of its business plan.”

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