Archive for the ‘Genomics & Pharmacogenomics’ Category
Molecular Target for Screening: G-Protein-Coupled Receptors
Last Updated on Friday, 20 August 2010 06:48 Written by Editor Thursday, 19 August 2010 03:10
Newark, DE. August, 2010 – Press Release – TimTec, LLC. – Molecular Target for Screening: G-Protein-Coupled Receptors, ActiTarg-G
G-Protein-Coupled Receptors are the largest gene families in the human genome and, rightfully so, have become the leading molecular target in 2008. In 2009 SBS April meeting in Lille, France, followed-up with screening trends report stating that “GPCRs are expected to replace protein kinases as the most common molecular target used by HTS laboratories.”
GPCRs are the largest family of cell surface receptors being integral to the number of cellular and physiological functions, including light sensing, smell, appetite control, insulin secretion, and blood pressure modulation. These receptors generally have a seven-membrane spanning alpha-helical topography, and while these receptors are similar in overall structure and function, they differ in key amino acid residues. The potential for this super family of receptors to reveal small molecule modulators of a significant biological function has been responsible for the focus of intense drug discovery efforts.
TimTec GPCR Ligands library is called ActiTarg-G. It currently counts 2,300 molecules available in various formatting options, and can be delivered in vials or in 96 or 384-well plates. ActiTarg-G is the set of diverse molecules that contain chemical lattices present in compounds reported in the technical or patent literature to possess GPCR-ligand properties.
Contact Information to schedule free consultation:
TimTec LLC
Harmony Business Park A-301
Newark DE 19711
Tel 302 292 8500
Fax 302 292 8520
Web: http://www.timtec.net/news/timtec-news/actitarg-g-gpcr-ligandshtml.html
About TimTec
TimTec LLC is a privately held company located in Newark Delaware, USA. It was founded in 1995 and began its work in the areas of acquisition and distribution of synthetic organic and natural compounds and collections, custom synthesis, and laboratory equipment to become a full service partner for drug discovery. TimTec has established a global network of thousands of scientists from research centers around the world. International customers include major pharmaceutical, biotech, agricultural, and educational companies and institutions, which use TimTec products for research and development programs.
CLC bio’s enterprise platform wins award at Bio-IT World Expo in Boston
Last Updated on Sunday, 10 May 2009 08:32 Written by admin Sunday, 10 May 2009 08:32
Boston, Massachusetts, USA — April 30, 2009 — CLC bio’s enterprise platform for Next Generation Sequencing data analysis, CLC Genomics Server, has just been awarded the “Best of Show†prize at the Bio-IT World Conference & Expo 2009 – an award judged by a team of Bio-IT World magazine editors and leading industry experts.
Bio-IT World Editor-in-Chief Kevin Davies, PhD., comments, “Each year we go through a process where our judging panel debates the technical merits and likely business impact of the different technologies presented at the Best of Show awards. CLC bio’s success this year clearly reflects the importance of the incredibly exciting Next Generation Sequencing space, with a solution that is obviously gaining traction with it’s capabilities to handle the immense data management and analytical challenges required in this area.â€
“Judging on several criteria, such as the importance of the problem being addressed and the elegance of the solution provided, it was clear to the judging panel that CLC Genomics Server, and the flexible plug-in structure it provides, delivers an ideal platform for researchers working with Next Generation Sequencing data.†says M. Michael Barmada, PhD. – member of the “Best of Show†judging panel and Director of the Center for Computational Genetics at the Graduate School of Public Health, University of Pittsburgh. “It’s nice to see complex computational algorithms and routines presented with an elegant interface in a user-friendly way, which lowers the technical barriers for all researchers working with high-throughput sequence data analysis.â€
CLC Genomics Server is CLC bio’s advanced and powerful bioinformatics solution which is built upon a powerful and modern three-tier server architecture, that yields flexible options of executing centralized services, easy integration with other applications and services, powerful database communication and data integration, and secure access control framework and central action logging. Customers already using this enterprise platform, includes J. Craig Venter Institute, Albert Einstein College of Medicine, Veridex, and University of California – Berkeley. Read more about this solution here:
http://www.clcbio.com/index.php?id=1376
GEN Reports on the Trend Toward Predictive Toxicogenomics
Last Updated on Thursday, 20 November 2008 01:00 Written by Editor Thursday, 20 November 2008 01:00
NEW ROCHELLE, N.Y., Nov 19, 2008 /PRNewswire via COMTEX/ — Biotech scientists increasingly are applying genomics technologies to toxicology research to better understand the effects of novel drug candidates on a variety of organ systems, reports Genetic Engineering & Biotechnology News (GEN). They are especially interested in figuring out a new compound’s mechanism of action and eventually developing a predictive toxicology technique, according to the November 15 issue of GEN. ( http://www.genengnews.com/articles/chitem.aspx?aid=2675)
SOURCE Genetic Engineering & Biotechnology News
Applied Biosystems and Asuragen Collaborate with the Critical Path Institute to Improve Drug Toxicity Screening
Last Updated on Tuesday, 11 November 2008 02:59 Written by admin Tuesday, 11 November 2008 02:59
The German Cancer Research Center Investigates the Role of miRNAs in Carcinogenesis Using febit’s Geniom RT Analyzer
Last Updated on Friday, 24 October 2008 02:14 Written by admin Friday, 24 October 2008 02:14
LEXINGTON, Mass. (USA), and HEIDELBERG, Germany, Oct. 20, 2008 – The German Cancer
Research Center, also known as DKFZ, in Heidelberg (Germany) chose febit´s newly
introduced Geniom® RT Analyzer to investigate the association of microRNAs (miRNAs)
and cancer.
miRNAs are small pieces of RNA with a maximum length of 23 nucleotides, which have
become an important focus of life-science research in the past couple of years.
Since they do not encode any proteins, they remained largely unappreciated for many
decades. Recently, however, scientists began to realize their crucial role in the
regulation of intracellular events such as differentiation or apoptosis of cells.
The number of miRNA being discovered is growing by the day.
DKFZ scientists therefore searched for a technology that would allow them to keep
pace with the rapidly evolving miRNA databases, continually incorporating the latest
information into their research on the role of miRNAs in carcinogenesis. The newly
developed Geniom RT Analyzer ideally meets this requirement: it exploits freely
configurable biochips produced on demand at febit for microarray analysis of miRNA
profiles in biological samples.
“Our positive experience with the flexibility of febit´s Geniom contributed to our
decision to use the new Geniom RT Analyzer,” said Joerg Hoheisel, director of the
DKFZ Functional Genome Analysis Division. “Preliminary tests indicate an excellent
quality of microarray analysis. In addition, my team is enthusiastic about the
straight-forward operation and outstanding efficiency of the instrument.”
In addition to flexibility, the Geniom RT Analyzer offers a high degree of
automation and numeÂrous user-friendly features: all steps in the workflow,
including sample addition, hybridization, staining, washing, shaking and detection,
are performed in one single instrument requiring a minimum of operator time. The
efficient operation results with minimal error rates and offer consistent
experimental parameters providing highly reproducible results. Data read out by the
Geniom Wizard software may then be analyzed with standard software solutions.
In addition to miRNA analysis, the Geniom RT Analyzer offers a variety of other
high-performance applications. For example, a patented biochip protocol enables the
fragmenÂtation and sorting of large genomes in smaller well-defined fractions.
Without this essential fractionation step, the complexity of the genomic DNA would
preclude any effective analysis. These may then serve as samples in mutation
analysis and high-throughput sequencing with next-generation sequencers.
febit’s new Geniom RT Analyzer combines extraordinary flexibility with a high degree
of automation for microarray analysis. (Photo: febit)
About febit
febit enables scientists to read, write and understand the code of life: DNA. With
its unique Geniom technology and services, febit is the only company that puts the
control of simplified genomic research in the hand of the user. The seamless
integration of DNA synthesis and analysis and the superior support in experiment
design and bioinformatics helps to understand data and turn it into results. febit’s
team of experienced scientists is dedicated to support customers to solve the
challenge of understanding biological processes. Geniom is a technological and
service platform successfully implemented in basic and applied research by renowned
institutions and companies. Geniom exploits cutting-edge microarray technology for
analysis and synthesis of genes and genomes, providing superior time- and
cost-efficiency combined with an unsurpassed spectrum of applications.
For more information about febit and its products please visit
www.febit.com
About the DKFZ, Division of Functional Genome Analysis
Research at the division of Functional Genome Analysis at the DKFZ (German Cancer
Research Center) aims at the development and immediate application of new
technologies for the production and processing of molecular information at a global
cellular level. The overall objectives are an analysis, assessment and description
of the realisation of cellular function from genetic information as well as the
understanding of the regulation of the relevant processes. Many projects are pursued
in national and international collaborations and programmes.
For more information on Functional Genome Analysis at the DKFZ, please visit
www.dkfz.de/funct_genome/
Posted under Cancer Research, Collaborations, Europe, Genomics & Pharmacogenomics, Press Releases, RNA Reasearch | No Comments
Cell-Based Assays: Innovations in Reagents, Technologies & Screening October 23 – 24, 2008
Last Updated on Thursday, 23 October 2008 12:56 Written by admin Wednesday, 22 October 2008 04:56
Cell-based assays provide one of the most valuable tools in drug discovery. They are routinely used in target validation, HTS campaigns, structure activity relationship analyses and ADMET studies. Many factors need to be considered in designing, developing and running relevant cell based assays to progress discovery programs. Significant advances continue to be made in assay design and cell supply processes that incorporate biologically relevant cell types and novel detection technologies. This symposium is designed to capture successful techniques and practices that enable high quality cell-based assays using commonly employed cell types such as CHO, HEK and U-2 OS, as well as the expanding application of additional cell types. The symposium will be of great interest to cell culture scientists, assay developers, screeners, medicinal chemists, ADMET and therapeutic teams.
Session Overviews:
Session 1: Cells as Reagents – Fact or Fiction?
This session will cover various aspects of the most important material used in cell-based assays: the cells. The talks will address the topics such as: how to characterize cell lines to ensure their identity? What are the impacts to the cells after transfection? What are the issues during scale up process? This session will also highlight advances in cell culture automation and material tracking system for cell-based assays.
Session 2: Assay Development – Present Realities
Topics covered include the application of BacMam virus based gene delivery in assay development, the development of high-content cellular assays, dielectric spectroscopy technology and photoprotein aqueorin based GPCR assay platforms and considerations in screening for antibody based therapeutics.
Session 3: Cell-Based Screening – The How, Why & Where
This session will include topics on the implementation of cell-based assays and screens across the discovery process focusing on the challenges, solutions and issues to consider. Presentations include experiences with high throughput screening for lead identification, profiling with cellular panels, ADME applications, and the use of high content screening in both drug discovery and to probe complex cellular systems.
Session 4: Cell-Based Assays – Emerging Trends
The topics in this session will address emerging trends in supply of cells that attempts to bridge the gap between traditional target based in vitro assays and in vivo measurements. The presentations will highlight potential applications of cells to build model systems that can offer the combined benefits of traditional in vitro and ex vivo approaches. These emerging technologies and methodologies hold the promise of addressing a major gap in using target based approaches to discover new biological tools and drugs and will challenge the supply of cell reagents.
http://www.sbsonline.com/
CLC bio Partners with Illumina to Provide Next Generation Sequencing Analysis Technology
Last Updated on Thursday, 2 October 2008 06:01 Written by admin Thursday, 2 October 2008 06:01
Aarhus, Denmark — October 2, 2008 — Following an overwhelming reception of CLC Genomics Workbench 1.0, CLC bio is happy to announce the release of its next major version of their flagship product: CLC Genomics Workbench 2.0. Additionally, CLC bio has taken another important step in leading next generation sequencing data analysis by becoming an Illumina Connect partner. Illumina Connect is a bioinformatics software partnership program established by Illumina, Inc. to advance data integration and analysis.
“CLC Genomics Workbench 2.0 provides scientists using Illumina’s Genome Analyzer with advanced downstream analysis,†says Jordan Stockton, Marketing Manager for Computational Biology at Illumina. “Not only is it fast, but the new version of CLC Genomics Workbench offers alignment and assembly functionality that previously required larger investments in computer hardware. With its intuitive graphical interface, this application provides a simple desktop solution to biologists who might otherwise require the assistance of a dedicated bioinformatics professional.â€
As an Illumina Connect partner, CLC bio has access to information in the ongoing development of Next Generation Sequencing tools, ensuring that CLC bio’s solutions will be able to fully support Illumina’s tools, including new releases.
Director of Scientific Software Solutions at CLC bio, Dr. Roald Forsberg states, “This release is inspired by the great advances in human genetics that are being powered by Next Generation Sequencing technologies, like Illumina. Large scale projects like the Cancer Genome Project and the 1000 Genomes Project are creating a vast amount of data that will transform biomedical research. However, before the revolution in human genetics can be fully realized by the research community there is a dramatic need for bioinformatics solutions that will allow biomedical researchers to handle and analyze sequencing projects at the human genomics scale – something we aim to solve with this and upcoming releases.â€
CLC Genomics Workbench 2.0 will include several prominent new features, among these:
A new and extremely fast algorithm for the assembly of short reads
Lowering of the memory requirements that makes it feasible to perform reference assembly against all human chromosomes on a standard computer
Easy masking of genomic regions such as repeat or coding regions to lower the genomic complexity and facilitate the fast mapping of CHiP-seq data or exon captured data
Easy combination of data across platforms and experimental protocols so that e.g. single read and paired ends data are easily combined into one analysis
CLC Genomics Workbench is the first and only comprehensive analysis package which can analyze and visualize data from all major NGS platforms, such as Illumina’s Genome Analyzer, SOLiD by Applied Biosystems, 454 GS flx by Roche, and HeliScope by Helicos. CLC Genomics Workbench is platform independent, running on Mac OS X, Windows, and Linux – including 64bit versions.
To read more about CLC Genomics Workbench go to: www.clcbio.com/genomics
About CLC bio
CLC bio is a world leading bioinformatics solution provider, solely focusing on the development of bioinformatics: software, hardware, data analysis, and custom-designed bioinformatics algorithms.
CLC bio’s mission is to be among the most innovative bioinformatics companies in the 21st century. This is realized through:
Focusing on Next Generation Sequencing downstream data analysis
Development of bioinformatics software and hardware based on the latest scientific findings
User-friendly, integrated and intuitive cross-platform software solutions
Continuous focus on customer needs and superior customer service
Frequent product updates including the latest IT technologies and bioinformatics algorithms
A flexible IT architecture, enabling customers to buy or develop individualized solutions at a reasonable price
Posted under BioInformatics, Collaborations, Europe, Genomics & Pharmacogenomics, Press Releases | No Comments
First of 100 Arab Human Genomes Sequenced by Saudi Biosciences, Beijing Genomics Institute Shenzhen, and CLC bio
Last Updated on Tuesday, 9 September 2008 03:06 Written by admin Tuesday, 9 September 2008 03:06
Riyadh, Kingdom of Saudi Arabia — September 9, 2008 — An international consortium consisting of Saudi Biosciences, Beijing Genomics Institute Shenzhen, and CLC bio have in a joint effort performed an initial sequencing and analysis of the first Arab human genome, as part of a large project to sequence 100 Arab human genomes to map the unique genetic variations of the Arab population.
His Royal Highness Prince Ahmad bin Sultan bin Abdulaziz, Head of the Board of Directors at Saudi Biosciences, said “This marks the first milestone in our goal to pioneer the personalized medicine era in the Arab world, and the next step is to lead a large project to sequence 100 Arab genomes at high resolution no later than the end of 2010. Our ambitions are to make this project go beyond similar international efforts, both in terms of quality and quantity!â€
Dr. Saeed Hussain from Saudi Bio Sciences, states, “We are extremely proud to present the first Arab human genome! This project launches the Kingdom of Saudi Arabia in to the small circle of nations who are currently in the process of building sophisticated databases of human genetic variation. This database is fundamental in the process of analyzing and understanding the specific genetic makeup of Arabs, which in turn will provide key knowledge to improve medical care for this large group of people.â€
How was the project realized?
After Saudi Biosciences launched this project early 2008, an international joint collaboration with Beijing Genomics Institute and CLC bio was organized.  A high quality sequencing of this genome was generated using Illumina’s Genome Analyzer platform. Afterwards the data was assembled and analyzed using CLC bio’s CLC Genomics Workbench.
“The fact that Saudi Biosciences have selected CLC bio among all the potential software providers, emphasizes that we are the world’s leading provider of genomics software solutions. We could think of no better opportunity to refine our software solutions, than a project like this, which is truly at the forefront of genomics research. This is indeed a unique and visionary project that we are excited and proud to be a part of.†said the Director of Scientific Solutions at CLC bio, Dr. Roald Forsberg.
The results, including analysis and identification of the unique variants of the Arab genome compared to African, European and Asian genomes, have been accumulated. The data are currently confidential but will be released following publication.
What is the impact of this project?
One of the most important goals of modern medicine and genetic research is the goal of tailoring medical care to an individual’s needs, based on information from the individual’s genotype or gene expression profile, so-called personalized medicine. Personalized medicine can offer huge advances in medical care but can only succeed if the genetic variation of humans can be accurately mapped.
The advent of a new generation of experimental techniques, has now given biomedical researchers the opportunity to map the complete genetic variation of large numbers of humans via full genome sequencing. The data produced from such efforts will provide an unparalleled amount of information that can be used to distinguish the unique groups within the human race, and help tailor medical care that targets the specific needs of different populations and individuals. Personalized medicine is thus on the brink of a major breakthrough.
However, the projects scheduled so far have aimed at characterizing mainly three populations – Africans, Europeans and Asians. This means that an accurate characterization and discovery of genetic variation in the Arab people can not be immediately expected and that the Arab populations may receive less of the benefits that will follow the advancement of personalized medicine.
This is why the Kingdom of Saudi Arabia wanted to start building an Arab human genomics database now, in order to scientifically explore the unique genetic composition in the Arab world. The database is fundamental in the process of analyzing and recognizing the distinct genetic makeup of Arabs, which in turn can provide knowledge to help stratify disease status, select between different medications and tailor their dosage, provide a specific therapy for an individual’s disease, or initiate a preventative measure that is particularly suited to that patient at the time of administration.
His Royal Highness Prince Ahmad bin Sultan bin Abdulaziz, Head of the Board of Directors at Saudi Biosciences, said “The Arab world was never an active participant in the large international projects in the field of genomics, and we believe that this should change. Working with an international collaborator such as Beijing Genomics Institute, an advanced institute in genomics studies, and CLC bio, the leaders in bioinformatics solutions with their recently released CLC Genomics workbench, we plan to participate actively in international efforts towards understanding the genomics basis of human diseases.â€
About Saudi Biosciences
Saudi Biosciences (SB) is a leading biotechnology company in the Middle East. SB main goal is to implement personalized medicine concept through studying the variations in Arabic populations. To achieve this goal, SB is sequencing 100 Arab genomes, exploring copy-number variations (CNV) and performing genome-wide association studies (GWAS) in collaboration with major institutes in Middle East.
About the Beijing Genomics Institute Shenzhen
The Beijing Genomics Institute Shenzhen (BGI) was founded in 1999. Since June of 2007, BGI has been headquartered in Shenzhen. It achieved international prominence as a center for sequencing the human genome. BGI completed one percent of the human genome for the Human Genome Project and ten percent of HapMap. Today the BGI staff of 500, led by Director Yang Huanming and Director Wang Jian, are in the forefront of genome research. Among other achievements, BGI has sequenced and mapped the rice and silk worm genomes. Current research includes sequencing of the panda genome as well as participation in the International HapMap project and the 1000 Genomes project.
About CLC bio
CLC bio is a world leading bioinformatics solution provider, solely focusing on the development of bioinformatics: software, hardware, data analysis, and custom-designed bioinformatics algorithms.
CLC bio’s mission is to be among the most innovative bioinformatics companies in the 21st century. This is realized through:
- Focusing on Next Generation Sequencing downstream data analysis
- Development of bioinformatics software and hardware based on the latest scientific findings
- User-friendly, integrated and intuitive cross-platform software solutions
- Continuous focus on customer needs and superior customer service
- Frequent product updates including the latest IT technologies and bioinformatics algorithms
- A flexible IT architecture, enabling customers to buy or develop individualized solutions at a reasonable price
Posted under Asia, BioInformatics, Collaborations, Genomics & Pharmacogenomics, Press Releases | No Comments
CLC bio release white paper on the world’s fastest Next Generation Sequencing assembly algorithm
Last Updated on Monday, 28 July 2008 07:03 Written by admin Monday, 28 July 2008 07:03
Aarhus Denmark — July 23, 2008 — CLC bio has just released a scientific white paper which confirms, that, in benchmarking tests, CLC bio’s new algorithm for assembly of Next Generation Sequencing data is the fastest one available. Not only is CLC bio’s algorithm considerably faster, but it also provides a better quality of the results, compared to other algorithms benchmarked in the white paper.
Assistant Professor at Rutgers University, Dr. Todd P. Michael, states, ‘The speed of CLC bio’s new algorithm for reference assembly of Next Generation Sequencing data raises the bar to a level currently unmatched by any competitor. When CLC bio continues this impressive rate of development, and eventually also handles SOLiD’s Color Space analysis in the same convincing manner, this could easily become a de facto tool for scientists working with Next Generation Sequencing analysis.’
Instead of using around 3 to 4 hours assembling 8.5 million reads against a whole human genome, CLC bio’s assembly algorithm accomplished the same calculation in little more than half an hour, which means at least 5 times faster than the closest competitor.
For the assembly of large data sets, the increase in speed is even bigger: When assembling 86 million reads against the whole human genome, CLC bio’s assembly algorithm is more than 14 times faster, meaning an assembly normally taking almost 40 hours can be done in less than two! At the same time, CLC bio’s algorithm provides a better quality of the results delivered with more than 85% accuracy, compared to around 83% for the other algorithms in the white paper.
Another highly interesting aspect of this improved assembly algorithm is the modest requirements of physical memory – at no point during the benchmark tests did CLC bio’s algorithm require more than 8GB RAM.
The benchmark tests were conducted by comparing both 8.5 million reads and 86 million reads against a whole human genome, kindly supplied by the Beijing Genomics Institute. The data set for the benchmark tests was sequenced on Illumina’s Solexa platform and each read had a length of 35 nucleotides.
Once the assembly algorithm will be released in August, it will be available both in a command-line version on CLC bio’s Bioinformatics Cell platform and through CLC Genomics Workbench, which offers an intuitive graphical interface for analyzing and visualizing Next Generation Sequencing data. CLC bio’s white paper is free to download for everyone at www.clccell.com/ngs
About CLC bio
CLC bio is the world’s leading full-service bioinformatics solution provider, solely focusing on the development of bioinformatics: software, hardware, data analysis, and custom-designed bioinformatics algorithms.
CLC bio’s mission is to be among the most innovative bioinformatics companies in the 21st century. This is realized through:
- Development of bioinformatics software and hardware based on the latest scientific findings
- User-friendly, integrated and intuitive cross-platform software solutions
- Continuous focus on customer needs and superior customer service
- Frequent product updates including the latest IT technologies and bioinformatics algorithms
- A flexible IT architecture, enabling customers to buy or develop individualized solutions at a reasonable price
AgriGenomics World Congress 2008 29-30 September 2008, Amsterdam, The Netherlands
Last Updated on Monday, 28 July 2008 05:57 Written by admin Monday, 28 July 2008 05:57
Select Biosciences is proud to announce their inaugural AgriGenomics World Congress. This year’s event will take place at the NH Grand Hotel Krasnapolsky in Amsterdam.
AgriGenomics.eu
Alongside an exhibition of selected scientific posters and service providers, Select Biosciences is organizing a two day event gathering some of the most influential players in the field from Europe, America and across the globe.
The agenda will include world leading research from renowned speakers including:
- Karen Century
Senior Scientist, Mendel Biotechnology - Jim Dunwell
Professor, University of Reading - Dominique Job
Laboratory Head, Bayer CropScience and CNRS - Johnathan Napier
Research Leader, Rothamsted Research - Andrew Paterson
Distinguished Research Professor and Director of the Plant Genome Mapping Laboratory, University of Georgia - Joseph Petolino
Senior Scientist, Dow AgroSciences - Tatiana Tatusova
Genome Group Coordinator, National Centre for Biotechnology Information, National Institutes of Health - And many more…
The full two day agenda includes the following sessions:
- Metabolic Engineering
- System-Based Approaches
- Informatics
- Traits & Applications
To guarantee a high attendance at this exciting event Select Biosciences will maintain their traditional low registration fees and group booking discounts.
Full conference passes include admission to all sessions and the exhibition as well as conference documentation.
Lunch, coffee breaks and the drinks reception provide ample time for networking and to continue discussions from the question and answer sessions.
The conferences division of Select Biosciences Ltd. is focused on organizing specialist biomedical meetings each year. Experts from both academia and commerce are invited to present timely information from current research through to commercial implementation of new technologies. These events also provide a unique networking facility and the opportunity to reach a highly targeted scientific audience.
www.selectbiosciences.com
Posted under Agriculture Research, Europe, Europe, Genomics & Pharmacogenomics, Press Releases | No Comments
CLC Genomics Workbench – CLC bio releases Next Generation Sequencing data analysis solution
Last Updated on Friday, 18 July 2008 07:00 Written by admin Friday, 18 July 2008 07:00
Aarhus, Denmark — June 12, 2008 — Today, CLC bio released their new Next Generation Sequencing (NGS) solution, CLC Genomics Workbench, which incorporates cutting-edge technology and algorithms, while also supporting and integrating with the rest of a typical NGS workflow.
CLC Genomics Workbench is the first comprehensive analysis package which can analyze and visualize data from all the major NGS platforms, such as SOLiD by Applied Biosystems, 454 GS flx by Roche Applied Science, Solexa by Illumina, and HeliScope by Helicos.
Director of Scientific Solutions at CLC bio, Dr. Roald Forsberg, PhD, states, “We set out to overcome two major challenges when analyzing Next Generation Sequencing data. One was to eliminate the analysis bottleneck by being able to analyze NGS data faster than it is produced. We overcame that by implementing an accelerated assembly algorithm in CLC Genomics Workbench which preliminary benchmark tests confirm is a very fast assembly algorithm. Secondly, we wanted to deliver user-friendly software which makes powerful NGS analysis software available to all biomedical researchers.â€
In benchmark tests, CLC bio has assembled half a million 454 reads against the full E.coli reference genome in around 2 minutes on a dual-core computer with 1 gigabyte RAM. This speed-up, based on integrated SIMD high-performance computing technology, increases even more when using a computer with more CPU-cores and RAM. CLC bio expects to release a benchmark white paper in the near future.
CLC Genomics Workbench 1.0 takes full advantage of “paired end†data, and supports a number of features and work-tasks, such as reference assembly of genomes, de novo assembly of genomes, SNP detection using advanced models, multiplexing, and high-throughput trimming.
Having completed the first version of CLC Genomics Workbench, CLC bio is already pursuing an ambitious development roadmap, which will enhance future softwares with features such as Digital Gene Expression, metagenomics, clustering and assembly of EST and cDNA sequences, large amounts of genomics and transcriptomics downstream analyses, and workflow support.
CLC Genomics Workbench has already been chosen as Next Generation Sequencing platform for all Danish universities. To read more about CLC Genomics Workbench go to: www.clcbio.com/genomics
About CLC bio
CLC bio is the world’s leading full-service bioinformatics solution provider, solely focusing on the development of bioinformatics: software, hardware, data analysis, and custom-designed bioinformatics algorithms.
CLC bio’s mission is to be among the most innovative bioinformatics companies in the 21st century. This is realized through:
- Development of bioinformatics software and hardware based on the latest scientific findings
- User-friendly, integrated and intuitive cross-platform software solutions
- Continuous focus on customer needs and superior customer service
- Frequent product updates including the latest IT technologies and bioinformatics algorithms
- A flexible IT architecture, enabling customers to buy or develop individualized solutions at a reasonable price
Posted under BioInformatics, ChemInformatics, Europe, Genomics & Pharmacogenomics, New Products, Press Releases | No Comments
Beijing Genomics Institute signs global site license with CLC bio for Next Generation Sequencing software platform
Last Updated on Friday, 18 July 2008 05:34 Written by admin Friday, 18 July 2008 05:34
Aarhus Denmark, July 3rd, 2008 – Beijing Genomics Institute (BGI) has signed a global site license agreement for CLC bio’s Next Generation Sequencing solution, CLC Genomics Workbench. The site license covers all researchers at all BGI sites, both inside and outside of China.
Head of Bioinformatics Division at BGI, Ruiqiang Li states, “We have chosen CLC Genomics Workbench as our platform for analyzing Next Generation Sequencing data after testing several commercial solutions, because it’s simply in a league of its own when it comes to flexibility and the way the Next Generation Sequencing tools can be used together with our own algorithms. In an organization of our size – with seventeen Illumina GA analyzers, as well as two AB/SOLiD and three Roche/454 Next Generation Sequencing machines, all of them running at full capacity – efficient workflows are of critical importance. We can support and expand our workflows by giving our scientists easy access via the Workbench to our own in-house developed algorithms. In no time, CLC Genomics Workbench has proved amazingly popular with our internal researchers, due to the fast, user-friendly and versatile platform it provides.â€
Director of Partner Sales at CLC bio, Michael Heltzen states, “We are most thrilled to have agreed on a global site license with one of the best bioinformatics and sequencing facilities in the world, only four weeks after our solution for analyzing and visualizing Next Generation Sequencing data was released. Furthermore, we are honored that the famous bioinformatics researchers from BGI have chosen our Workbench as a working platform for both our and their own algorithms, side by side. CLC Genomics Workbench will help the scientists at BGI with their daily research, including prestigious projects like the Giant Panda Genome Project and the 1000 Genomes Project.â€
CLC Genomics Workbench is the first comprehensive analysis package which can analyze and visualize data from all the major NGS platforms, such as Solexa by Illumina, SOLiD by Applied Biosystems, 454 by Roche Applied Science, and HeliScope by Helicos. CLC Genomics Workbench takes full advantage of “paired end” data and supports a number of features and work-tasks, such as reference assembly of genomes, de novo assembly of genomes, SNP detection using advanced models, multiplexing, and high-throughput trimming. Read more about it at: www.clcbio.com/genomics
CLC Genomics Workbench is available for Mac OS X, Windows and Linux.
About Beijing Genomics Institute
Beijing Genomics Institute is one of the leading global Genomics Institutes in the world, established in July 1999. Since then, BGI has grown rapidly and is partner in a number of international consortiums, including partnerships with the Wellcome Trust Sanger Institute, NIH and NHGRI on the 1,000 Genomes Project. BGI now has a number of research locations including major sites in Shenzhen and Beijing.
BGI aims to advance the understanding of biology and medicine through the use of large-scale sequencing and bioinformatics analysis. The institute also offers sequencing services to the international community. BGI promotes the use of genome-scale scientific approaches and strongly supports collaborative efforts in order to achieve this goal.
For further information, please contact:
Jia Ye, Spokesperson
Beijing Genomics Institute, Shenzhen
Tel: +86 755 25273910
Fax: +86 755 25273620
E-mail yejia@genomics.org.cn
About CLC bio
CLC bio is the world’s leading full-service bioinformatics solution provider, solely focusing on the development of bioinformatics: software, hardware, data analysis, and custom-designed bioinformatics algorithms.
CLC bio’s mission is to be among the most innovative bioinformatics companies in the 21st century. This is realized through:
- Development of bioinformatics software and hardware based on the latest scientific findings
- User-friendly, integrated and intuitive cross-platform software solutions
- Continuous focus on customer needs and superior customer service
- Frequent product updates including the latest IT technologies and bioinformatics algorithms
- A flexible IT architecture, enabling customers to buy or develop individualized solutions at a reasonable price
Posted under Asia, BioInformatics, ChemInformatics, Collaborations, Genomics & Pharmacogenomics, North America, Press Releases | No Comments
World Premiere of Next Generation Sequencing solution from CLC bio
Last Updated on Friday, 25 April 2008 05:02 Written by admin Friday, 25 April 2008 05:02
Boston, USA — April 25, 2008 — On Monday, April 28, CLC bio will officially unveil their new Next Generation Sequencing solution, CLC Genomics Workbench, the first comprehensive analysis package which can analyze and visualize data from all the major Next Generation Sequencing (NGS) platforms, such as SOLiD from Applied Biosystems, 454 GS flx from Roche Applied Science, Solexa from Illumina, and HeliScope from Helicos. The World Premiere is at the Bio-IT World Conference & Expo,April 28 – April 30, at the World Trade Center in Boston, USA.
Vice President of CLC bio, Jan Lomholdt, states, Having experienced massive pre-release interest from people within the Next Generation Sequencing segment, we’re confident that our cross-platform NGS solution which includes an intuitive graphical interface, numerous downstream analyses, and support for all the major NGS platforms, will become a hit. Especially when taking into consideration that we have assembled half a million 454 reads against the full E.coli reference genome, in around 2 minutes on a Dual-core laptop with 1 gigabyte RAM. In other words: This is FAST!â€
“There is an explosion of interest in the next generation sequencing field right now, and I’m confident that CLC Genomics Workbench will become a valuable tool for the rapidly growing number of users in academia and industry who are using these new instruments for an amazing range of applications,†said Bio-IT World Editor-in-Chief Kevin Davies, PhD. “We’re also delighted that CLC bio has choosen this year’s Bio-IT World Expo in Boston to announce and introduce this product to the scientific and informatics communities.â€
CLC Genomics Workbench includes accelerated assembly of Next Generation Sequencing data through use of High Performance Computing technology, making the assembly process very fast. The genomes to be assembled can be of any size, only limited by the number of gigabytes of RAM available on the computer running the assembly.
CLC Genomics Workbench takes full advantage of “paired end†data, and supports a number of features and work-tasks, such as reference assembly of genomes, De Novo assembly of genomes, SNP detection using advanced statistical models, Digital Gene Expression, metagenomics, clustering and assembly of EST and cDNA sequences, large amounts of genomics and transcriptomics downstream analyses, and workflow support. Some of the mentioned features will be implemented in future releases.
CLC Genomics Workbench has already been chosen as Next Generation Sequencing platform for all Danish universities. CLC bio will release CLC Genomics Workbench to the public in late May. To read more about CLC Genomics Workbench go to: www.clcbio.com/genomics
About CLC bio
CLC bio is the world’s leading full-service bioinformatics solution provider, solely focusing on the development of bioinformatics: software, hardware, data analysis, and custom-designed bioinformatics algorithms.
CLC bio’s mission is to be among the most innovative bioinformatics companies in the 21st century. This is realized through:
Development of bioinformatics software and hardware based on the latest scientific findings
User-friendly, integrated and intuitive cross-platform software solutions
Continuous focus on customer needs and superior customer service
Frequent product updates including the latest IT technologies and bioinformatics algorithms
A flexible IT architecture, enabling customers to buy or develop individualized solutions at a reasonable price
Posted under BioInformatics, Genomics & Pharmacogenomics, North America, Press Releases | No Comments
CLC bio and University of Copenhagen Sign Site License Agreement
Last Updated on Tuesday, 11 March 2008 05:05 Written by admin Tuesday, 11 March 2008 05:05
Copenhagen & Aarhus Denmark, March 11, 2007 — CLC bio and Department of Biology, Faculty of Science at University of Copenhagen, have signed a site license agreement for CLC bio’s premier bioinformatics software solution, CLC Combined Workbench, in combination with CLC bio’s Educational Suite. The deal runs for five years and is for several hundred seats, giving every researcher, student and teacher access to the software at all times.
The Head of Department of Biology at University of Copenhagen, Professor Dr. Lene Lange states,
‘We chose CLC bio as our solution provider as CLC Combined Workbench provides cutting edge algorithms and analyses of a high scientific standard, which is fundamental for our research. Also the wide range of tools available in this single application will eliminate a lot of tedious tasks, importing, exporting, and converting data between various applications – and thus help us improve our workflow, freeing up valuable time for research. We’re also looking forward to using CLC Educational Suite as a solid backbone for our bioinformatics courses.’
University of Copenhagen’s Department of Biology is organized in different Research Centers which are involved in international top tier research collaborations. They are funded from sources like the European Union and the Bill & Melinda Gates Foundation, among others. The many projects range from retrieval of ancient DNA from fossils (Center for Ancient Genetics), bioinformatics, gene regulations and SNP (Cancer Research), complex dependent mutations, primates genome evolution (The Genomics Group), whole genome sequencing of hyperthermophilic archaea bacteria (Archaea Biology Group), muscle biology (Copenhagen Muscle Research Center) to studies of how climate changes affects distribution of life on Earth (Center for Macroecology).
CLC Combined Workbench is a comprehensive software solution for advanced DNA, RNA, and protein analyses, containing all features of CLC DNA Workbench, CLC RNA Workbench, and CLC Protein Workbench in one, integrated software package. The program will replace the whole range of outdated and expensive tools, which the research centers have been using previously. CLC Combined Workbench is available for Mac OS X, Windows, and Linux
About CLC bio
CLC bio is the world’s leading full-service bioinformatics solution provider, solely focusing on the development of bioinformatics: software, hardware, data analysis, and custom-designed bioinformatics algorithms.
CLC bio’s mission is to be among the most innovative bioinformatics companies in the 21st century. This is realized through:
Development of bioinformatics software and hardware based on the latest scientific findings
User-friendly, integrated and intuitive cross-platform software solutions
Continuous focus on customer needs and superior customer service
Frequent product updates including the latest IT technologies and bioinformatics algorithms
A flexible IT architecture, enabling customers to buy or develop individualized solutions at a reasonable price
Posted under BioInformatics, Europe, Genomics & Pharmacogenomics, North America, Press Releases | No Comments
Seaside Therapeutics Awards $4.5 Million Collaborative Research Contract to Vanderbilt University Medical Center
Last Updated on Monday, 4 February 2008 04:13 Written by Fred Monday, 4 February 2008 04:13
Seaside Therapeutics announced today the award of a $4.5 million collaborative research contract to Vanderbilt University Medical Center to discover novel compounds to potentially suppress the manifestations of fragile X syndrome. Fragile X syndrome is the most common inherited disorder of brain development and the most common known genetic cause of autism. Individuals with fragile X can suffer from impaired cognitive function, developmental delay, attention deficit and hyperactivity, anxiety, obsessive-compulsive and autistic behaviors.Research conducted by Seaside founders and others in the field has indicated that excessive signaling through metabotropic glutamate receptor subtype 5 (mGluR5) may be responsible for the neurological and psychiatric consequences of fragile X syndrome. Seaside believes that selective inhibition of this receptor could potentially reduce or eliminate the devastating effects of fragile X syndrome.
Scientists at Vanderbilt, led by Dr. Jeffrey Conn, Director of the Vanderbilt Program in Drug Discovery, principal investigator of the fragile X project and a member of Seaside’s Scientific Advisory Board, have identified more than 400 novel compounds belonging to multiple chemical classes that inhibit mGluR5. With the support of the Seaside Therapeutics’ funding, Vanderbilt researchers will use medicinal chemistry, molecular biology, pharmacology, and efficacy studies to develop compounds that have the properties required for drugs to be used for further study in fragile X. Seaside Therapeutics will collaborate with Vanderbilt on this project by contributing scientific and drug development expertise, particularly as related to fragile X syndrome, autism and other disorders of brain development. Seaside will also select compounds from the collaboration to carry forward into clinical development.
“There are currently no effective treatments for fragile X syndrome,†said Dr. Randall Carpenter, Co-Founder, President and CEO of Seaside Therapeutics. “Seaside believes the best approach to identifying new treatments is to use our own research to discover and validate specific biological sites that play a role in fragile X, and then, either internally or in collaboration with others, develop therapeutics that modulate these biologic targets. We’re excited to work with the team at Vanderbilt given their expertise in drug discovery and, most importantly, because they share Seaside’s passion for helping children with fragile X—creating a strong partnership focused on rapidly translating new discoveries in neurobiology into desperately needed novel treatments.â€
“Selectively inhibiting mGluR5 to treat fragile X is an innovative idea and, with continued success, has the potential to change the way people think about developmental disorders,†said Dr. Jeffrey Conn. “While we are at the very earliest stages in the drug discovery process, my team members and I are hopeful we can help advance research efforts in fragile X.â€
About Fragile X
Fragile X syndrome is relatively rare, affecting approximately 90,000 people in the United States. It is caused by a mutation in the FMR1 gene on the X chromosome that prevents expression of a single protein, the fragile X mental retardation protein (FMRP). The absence of FMRP gives rise to the major symptoms of fragile X syndrome in humans—impaired cognitive function, developmental delay, attention deficit and hyperactivity, anxiety, obsessive-compulsive and autistic behaviors. A key advance for understanding fragile X was identification of the FMR1 gene and subsequent generation of the Fmr1 knockout mouse—an animal model that lacks FMRP and mimics the human condition. By studying the brain of these mice, Seaside scientific founder Mark Bear, Ph.D., the Picower Professor of Neuroscience at the Massachusetts Institute of Technology’s Picower Center for Learning and Memory, discovered a connection between metabotropic glutamate receptor subtype 5 (mGluR5) signaling and fragile X syndrome. Metabotropic glutamate receptors are activated by the neurotransmitter glutamate. Studies by Bear and others indicate that excessive signaling through mGluR5 may be responsible for the neurologic and psychiatric consequences of fragile X syndrome, and suggest that selective mGluR5 inhibitors will provide therapeutic benefit to this population.
About Seaside Therapeutics
Seaside Therapeutics is creating new drug treatments to correct or improve the course of fragile X syndrome, autism and other disorders of brain development. We are dedicated to translating breakthrough discoveries in genetics and neurobiology into therapeutics that improve the lives of patients and their families.
About Vanderbilt University Medical Center and the Vanderbilt Program in Drug Discovery
Vanderbilt University Medical Center is a major referral center for the Southeast and nation. It is made up of Vanderbilt University Hospital, The Vanderbilt Clinic, The Monroe Carell Jr. Children’s Hospital at Vanderbilt, Vanderbilt School of Medicine and Vanderbilt School of Nursing. VUMC is the largest private employer in the region, employing more than 10,000 employees and generating an annual regional economic impact of over $1 billion.
The primary mission of the Vanderbilt Program in Drug Discovery is to facilitate the application of chemical and other technologies to answer fundamental questions in the biological sciences that may ultimately lead to the development of novel therapeutic strategies. Vanderbilt scientists led by Dr. Jeffrey Conn, Director of the Vanderbilt Program in Drug Discovery, have pioneered the discovery of “allosteric†compounds that modulate (“turn up†or “turn downâ€) the activation of certain receptors, called metabotropic glutamate receptors, when the neurotransmitter glutamate binds to them. Using Vanderbilt’s high-throughput screening facility, which is capable of testing tens of thousands of small molecules for drug-like activity in a single day, Dr. Conn and his colleagues have identified more than 400 compounds with mGluR5 inhibitory effects.
ERA-NET PathoGenoMics recognises outstanding PhD theses
Last Updated on Thursday, 25 October 2007 12:29 Written by admin Thursday, 25 October 2007 12:29
Increasingly, disease-causing microorganisms are being analysed on a genetic level in the hope of identifying critical factors that might be therapeutically applicable. European research in this area is being promoted under the roof of the ERA-NET PathoGenoMics network. During the 3rd European Conference on Procaryotic Genomics, held from 7 to 10 October in Göttingen, Germany, the network recognised three outstanding pathogenomic PhD theses. This year is the second time the prize has been awarded. The winners were selected from ten applications.
The ERA-NET PathoGenoMics was initiated in 2004 by the German Federal Ministry of Education and Research (BMBF) and is a network of 15 partners from Austria, Finland, France, Germany, Hungary, Israel, Latvia, Portugal, Slovenia and Spain. Their aim is to promote genomic research on pathogenic microorganisms (pathogenomics) taking place in Europe. It was initiated in 2004 and is one of around 70 ERA-NET networks aimed at counteracting the fragmentation of the European Research Area. The ERA-NET scheme is a funding instrument of the European Commission, first introduced in the Sixth Framework Programme. The underlying intention is to step up the cooperation in research activities carried out at a national or regional level in the member states.
For the second time, the ERA-NET PathoGenoMics has recognised outstanding PhD theses in the field of pathogenomics research. The annual prize is endowed with 2000 Euros for each winner. This year, three reseachers have been chosen from a total of ten applications: Christel Archambaud (France), Cédric Delevoye (France) and Joâo Paulo dos Santos Gomes (Portugal). The official award ceremony took place during the 3rd European Conference on Procaryotic Genomics in Göttingen, Germany, on 8 October. Following an introduction by Nicole Firnberg (Austria), the winning researchers had the opportunity to present the results of their thesis. The researchers were later presented with their awards by the French scientist Philippe Glaser (Institute Pasteur, Paris): a large petri dish with synthetic resin as imitation agar, through which the official award certificate can be seen, as well as a hard copy of the certificate rolled in a volumetric flask.
Christel Archambaud from the Institut Pasteur in Paris has focused on the analysis of a special enzyme family involved in signal transduction (phosphatases) and its role in the pathogenicity of Listeria monocytogetes, which can cause a number of deadly infections due to its sophisticated survival and reproduction strategy once it has entered a host. In her PhD thesis, Archambaud has identified a functional phosphatase (Stp) that appears to be crucial for the virulence of Listeria.
Cédric Delevoye, working at the Institute Curie in Paris, has analysed the intracellular infection cycle of Chlamydia. Chlamydia is a sneaky bacterial genus that can only reproduce from within host cells and causes chronic infections that are extremely difficult or impossible to treat. In his PhD thesis, Delevoye focussed on identifying membrane proteins that are secreted by Chlamydia pneumoniae during infection. In addition, he functionally characterised a single protein from the IncA-family that appears to be essential for cellular membrane fusion events.
Joâo Paulo dos Santos Gomes, working at the National Institute of Health in Lisbon, studied biological and genetic features of Chlamydia trachomatis serological variants to reveal their different pathogenic potential. Dos Santos Gomes identified highly polymorphic so-called pmp genes as playing a significant role in infection and transmission ability based on transcriptomic and immunoactivity analysis. Furthermore, he found recombination among strains to be a mechanism for generating Chlamydia trachomatis diversity.
Research group leaders from the ERA-NET partner countries are now invited to submit a proposal for the PhD Award 2008. Deadline for submissions is the 28 February 2008. For national contact details see www.pathogenomics-era.net
Posted under Education, Europe, Genomics & Pharmacogenomics, Grants and Awards, Press Releases | No Comments
Strategic Diagnostics Launches Initial Oncology-Targeted Antibody Reagent Catalog
Last Updated on Thursday, 18 October 2007 01:11 Written by admin Thursday, 18 October 2007 01:11
NEWARK, Del., Oct. 2 /PRNewswire-FirstCall/ — Strategic Diagnostics Inc. — today announced the launch of a new internet based catalog of antibody reagents in support of oncology-based research and discovery. These high-quality reagents have all been manufactured utilizing SDI’s proprietary Genomic Antibody Technology(TM) and will carry the SEQer(TM) brand. The catalog is available at http://antibodies.sdix.com online.
The catalog has launched with an initial offering of over 200 affinity purified antibody reagents. The Company will supplement this with up to an additional 25 new reagents each week as it strives to become recognized as the fastest-growing site of high quality, leading edge reagents for cancer research.
“Standard antibody production technologies have not changed in more than 20 years,” commented Matthew H. Knight, the Company’s President and Chief Executive Officer. “The SEQer antibodies in this catalog represent a breakthrough in antibody production and deliver multiple high performance attributes that reduced time, effort and data variation in the laboratory. In addition, the process that produces these reagents is high throughput as evidenced by our initial commitment to add up to 25 new antibody reagents each week. As recognition of SEQer antibody performance grows, we intend to increase this rate.”
Mr. Knight continued, “The launch of the SEQer catalog is a direct response to market research highlighting how the Life Science industry and particularly proteomics research has been inhibited by to the lack of high quality antibody reagents. The National Cancer Institute convened the Proteomic Technologies Reagents Resource Workshop in December, 2005, to identify the cancer research community’s expressed needs for validated and well characterized affinity capture reagents, including antibodies, to advance proteomics research platforms for the prevention, early detection, treatment, and monitoring of cancer. Many of the available catalogs typically broker pre-made antibodies from multiple sources and fall well short of meeting the performance needs of today’s biomedical researchers. With the launch of the SEQer catalog, Strategic Diagnostics is taking the first step to address this research bottleneck and meet a surging demand. We expect to build the fastest-growing source of oncology-focused antibody reagents which represents a meaningful share of the highly fragmented, $800 million annual market for catalog reagents.”
Strategic Diagnostics’ Genomic Antibody Technology(TM) (GAT) platform
Genomic Antibody Technology(TM) is a proprietary technology developed by Strategic Diagnostics (SDI). This high throughput, sequence-based, in vivo production process creates high-quality poly- or monoclonal reagents used in the discovery of new diagnostic biomarkers, unraveling the underlying mechanisms of disease, and as the basis of potential monoclonal antibody therapeutics. These antibodies are produced in 76 days and early adopters have tracked a first-time success rate in excess of 80%. SDI’s proprietary protein analysis software selects the optimal sequence associated with the specific protein or protein region the researcher wants to target and/or avoid. GAT expresses protein in vivo, thus assuring that the antigen targets and fully engages the natural mammalian immune system. This enables the production of an antibody that reacts more often and with greater fidelity when compared to reagents produced through traditional methods.
The SEQer catalog of antibodies addresses a number of well-known challenges associated with currently available reagents. Specifically, deficiencies in the ability to replicate the three dimensional conformation of target proteins through synthetic immunogens have resulted in reagents that do not reliably recognize or differentiate their intended targets. This, in turn, limits reagent performance and creates a level of uncertainty regarding the data produced with traditionally produced reagents. The SEQer antibody is focused on addressing the loss of productivity in research and development endeavors.
“The performance of our SEQer antibodies has been demonstrated with our many private and public collaborators in numerous assays,” Mr. Knight said. “The programs have included significantly large screens for oncology markers and the ability to stain disease-associated proteins across thousands of clinical biopsy samples. More targeted studies have shown the ability to differentiate highly conserved proteins in cell sorting assays, the ability to react with traditionally elusive proteins of interest, and be directed through SDI’s design algorithms to target functional sites in monoclonal applications.”
SDI’s GAT-produced antibodies are significantly better than traditional protein/peptide-produced antibodies, as they are produced in vivo by the host animal’s natural immune system, and are therefore able to behave both chemically and mechanically as any naturally produced antibody would.
Oncology Focus
The SEQer oncology-focused portfolio is comprised of antibody tools that target proteins associated with cancer pathogenesis and progression, thereby succeeding in delivering usable data for more proteins and in more applications. SDI strategically focused on the area of oncology, as more than half of NIH-funded research and the majority of proteomic efforts are currently focused on cancer research.
“SDI is focused on the oncology segment of life science research and is committed to creating industry leading solutions for oncology research,” Mr. Knight added. “This initial offering is a powerful step in that direction. As we expand this catalog, it will become the premier site for new and important antibody reagents for cancer research.”
About Strategic Diagnostics, Inc.
Strategic Diagnostics Inc. develops, manufactures and markets biotechnology-based detection solutions to a diverse customer base, across multiple industrial and human health markets. By applying its core competency of creating custom antibodies to assay development, the Company produces unique, sophisticated diagnostic testing and reagent systems that are responsive to customer diagnostic and information needs. Customers benefit with quantifiable “return on investment” by reducing time, labor, and/or material costs. All this is accomplished while increasing accuracy, reliability and actionability of essential test results. The Company is focused on sustaining this competitive advantage by leveraging its expertise in immunology, proteomics, bio-luminescence and other bio-reactive technologies to continue its successful customer-focused research and development efforts. Recent innovations in high throughput production of antibodies from genetic antigens will complement the Company’s established leadership in commercial and custom antibody production for the Research, Human/Animal Diagnostics, and Pharmaceutical industries, and position the Company for broader participation in the pharmacogenomics market.
This news release contains forward-looking statements reflecting SDI’s current expectations. When used in this press release, the words “anticipate”, “could”, “enable”, “estimate”, “intend”, “expect”, “believe”, “potential”, “will”, “should”, “project” “plan” and similar expressions as they relate to SDI are intended to identify said forward-looking statements. Investors are cautioned that all forward-looking statements involve risks and uncertainties, which may cause actual results to differ from those anticipated by SDI at this time. Such risks and uncertainties include, without limitation, changes in demand for products, delays in product development, delays in market acceptance of new products, retention of customers and employees, adequate supply of raw materials, the successful integration and consolidation of the Maine production facilities, inability to obtain or delays in obtaining fourth party, including AOAC, or required government approvals, the ability to meet increased market demand, competition, protection of intellectual property, non-infringement of intellectual property, seasonality, and other factors more fully described in SDI’s public filings with the U.S. Securities and Exchange Commission.
Posted under Cancer Research, Genomics & Pharmacogenomics, North America, Press Releases, Proteomics, Reagents | No Comments
European research agenda for pathogenomics adopted
Last Updated on Thursday, 31 May 2007 05:03 Written by admin Thursday, 31 May 2007 04:50
Network of Excellence EuroPathoGenomics has undergone its first review
Researchers have long been fascinated by microorganisms, as they can be both useful inhabitants of the body and dangerous pathogens. In 2005, to better understand this dual role, 37 researcher teams from 13 different European countries founded the Network of Excellence EuroPathoGenomics (NoE EPG). The members have now adopted a common Research Agenda for the field of pathogenomics, which lays out the core scientific challenges for the years to come and places emphasis on two aims in particular: In future, scientists intend to focus more on the interaction between the pathogens and the hosts, rather than exclusively analysing disease-causing microorganisms in isolation. Furthermore, the microbiologists’ aim is to strengthen cooperation with bioinformatic experts, in order to better manage the multitude of data that is produced in modern genomic research.
For decades, researchers have concentrated on the microorganisms that cause diseases. More recently however, thanks to the tools of modern genomics, they have been able to focus in detail on the molecular mechanisms behind the pathogens. To bundle European competencies in the field of pathogenomics and to strengthen the exchange of experiences, a total of 37 scientific laboratories from 13 different countries came together in 2005 under the umbrella of the European Network of Excellence EuroPathoGenomics NoE EPG. This initiative is being funded by the European Commission with 6.7 millions euros over five years. At the end of April, at a meeting in the Villa Vigoni in Italy, members undertook a first review of their cooperation. “Over the course of the previous years, we have focused mainly on establishing efficient infrastructures and making them available for all partners”, said Prof. Jörg Hacker from the University of Würzburg, who is coordinating the network. In particular, a central virtual cell strain collection has been completed, which allows for the rapid searching of suitable data. Furthermore, the “EuroPathoGenomics Graduate Academy” (EGA) has also been established, with more than 50 students participating in a number of training programmes.
In the future, NoE EPG-members intend to concentrate more on the strategic adjustment of their work with the aim of improving the coordination of research across the participating countries. In Italy, the network partners therefore adopted the first structure of a common European research agenda, which describes the most important challenges in pathogenomics that the scientists will be facing in the coming years. “In the long run, we have to focus more on analysing the interaction of the pathogens with the host as well as shedding light on the complex interplay between different microorganisms that are active at the same time”, said Hacker. Furthermore, in their daily work, the pathogenomics experts are confronted with the enormous quantity of data that results from genomic research. The scientists want to address this problem with the development of new bioinformatic approaches, which could particularly advance the comparison of different pathogenic genomes. “We have to use comparative genomics to discover both the molecular determinants that cause hospital infections and the factors that are responsible for the drug-resistance of pathogens”, said Mike Gilmore, Harvard Medical School, USA, at the meeting. Another goal of the agenda is better cooperation between basic scientists and clinicians. “Our scientific language is not well understood by clinicians. We should learn more from each other”, emphasised the German researcher Werner Goebel from the University of Würzburg,during the meeting in Italy.
More information: www.noe-epg.uni-wuerzburg.de
Posted under Genomics & Pharmacogenomics, PathoGenomics, Press Releases, Research Projects | No Comments
BioServe Names Kevin Krenitsky as Chief Executive Officer
Last Updated on Thursday, 31 May 2007 03:17 Written by admin Thursday, 31 May 2007 03:17
Beltsville, MD, May 7, 2007 – BioServe today strengthened its senior management team with the appointment of Kevin Krenitsky, M.D. as Chief Executive Officer. Krenitsky is a highly respected 15-year veteran of the life sciences industry, bringing a wealth of experience in building and managing global biotechnology operations.
“Kevin’s impressive range of experience in diagnostics, pre-clinical and clinical pharma, along with his in depth knowledge of our recently acquired Genomics Collaborative bio-banking business makes him the perfect fit to lead BioServe into the future,†said Rama Modali, Founder and President, BioServe. “Kevin’s operational experience along with his successful experience in launching new products and service offerings will be instrumental in growing BioServe’s global business. We are pleased that Kevin has joined BioServe and look forward to his contributions to the team.â€
Prior to joining BioServe, Dr. Krenitsky was the Chief Executive Officer of Parkway Clinical Laboratories, a clinical diagnostic lab providing comprehensive routine and esoteric testing. Prior to that he served as Senior Vice President and Division Head at SeraCare Life Sciences’ Genomics Collaborative Division (GCI) where he managed all worldwide pharmaceutical R&D collaborations. Before GCI was acquired by Seracare Life Sciences, Dr. Krenitsky acted as the company’s Medical Director responsible for spearheading the development of GCI’s global network of five hundred-plus clinical sites on four continents. During his tenure at GCI, Dr. Krenitsky was instrumental in developing several hundred agreements with dozens of major pharmaceutical, biotechnology, and diagnostic companies worldwide. Dr Krenitsky received his M.D. from Jefferson Medical College.
Dr. Krenitsky commented, “I am extremely excited to join BioServe, a company that has forged a stellar reputation for genomic analysis among many of the world’s leading researchers. With the addition of the Genomics Collaborative bio-bank to the company’s comprehensive services, BioServe is on track to become the leader in helping researchers discover and validate a new generation of superior diagnostic and therapeutic targets.”
About BioServe
BioServe provides a comprehensive ‘biomaterial to validated data’ genomics services platform, helping researchers gain the pre-clinical data for breakthroughs in drug discovery, molecular diagnostics and pharmacogenomics. Utilizing BioServe’s genomics services platform, researchers can identify genetic markers, validate drug targets that cause disease and correlate clinical data with molecular data to accelerate the development of new and safer drugs. BioServe’s services extend from nucleic acids processing, DNA synthesis, high throughput sequencing and genotyping, genome wide-scans and gene expression analyses to ready-made large epidemiologically sound case-control studies of inflammatory disorders, endocrine disorders, cardiovascular disease, diabetes, hypertension, obesity and many cancers. BioServe’s Global Repository® provides researchers with a library of 600,000 human DNA, tissue and serum samples linked to detailed clinical and demographic data from 140,000 consented and anonymized patients from four continents. BioServe’s customers include leading pharmaceutical and biotechnology companies, and government and academic research institutions. BioServe has headquarters in Beltsville, MD and Hyderabad, India. For more information please visit www.bioserve.com or call 301-470-3362.
Posted under Cancer Research, Genomics & Pharmacogenomics, North America, Press Releases | No Comments
BioServe Acquires Genomics Collaborative
Last Updated on Friday, 4 May 2007 07:21 Written by admin Friday, 4 May 2007 07:20
BioServe Extends Genomics Services Platform with Premier Industrial Biobank for Biomarker Discovery and Validation
Beltsville, MD, May 1st, 2007 – BioServe, a leading provider of genomics services, today announced that it has acquired Genomics Collaborative from SeraCare Life Sciences, Inc. Genomics Collaborative is a leader in facilitating biomarker discovery and validation through its Global Repository®, a comprehensive library of 600,000 human DNA, tissue and serum samples linked to detailed clinical and demographic data from 140,000 consented and anonymized patients collected on four continents.
Through this acquisition BioServe significantly expands its pre-clinical product and service capabilities to provide organizations engaged in drug discovery and diagnostic development with a comprehensive “biomaterial to validated data†services platform. This service platform extends from molecular research products and services such as DNA and RNA purification reagents, DNA sequencing, oligonucleotide synthesis and genotyping to ready-made large epidemiologically sound case-control studies of inflammatory disorders, endocrine disorders, cardiovascular disease, diabetes, hypertension, obesity and cancers including breast, prostate, lung and colorectal.
“The acquisition of Genomics Collaborative firmly positions BioServe as a preferred partner for pre-clinical discovery and validation studies. Working with BioServe, drug discovery researchers have the flexibility to tap the Bio Repository to augment their in house sample sets, design entire genomic studies around our sample library, and further benefit from BioServe’s proven ability to process and analyze vast quantities of genomic content,†said Rama Modali, President, BioServe. “BioServe’s complete biomaterial to validated data approach will help researchers identify the genetics markers, biochemical pathways and drug targets that cause disease to accelerate the development of new and safer drugs.â€
BioServe will continue to offer the GCI Access programâ„¢, which allows researchers around the world to access human DNA, RNA, serum and tissue samples with comprehensive informed consent and detailed clinical data, on a fee for service basis.
Genomics Collaborative will operate as a fully integrated division of BioServe, offering its DNA, tissue and serum Global Repository® samples to BioServe’s customers worldwide. The Genomics Collaborative clinical team, led by Vice President of Medical Affairs, George Taylor MD, has joined BioServe and will further add to the company’s expertise in genomics, epidemiology, biostatistics and molecular biology.
BioServe will be exhibiting at the BIO 2007 International Annual Convention as part of the State of Maryland pavilion.
About BioServe
BioServe provides a comprehensive ‘biomaterial to validated data’ genomics services platform, helping researchers gain the pre-clinical data for breakthroughs in drug discovery, molecular diagnostics and pharmacogenomics. Utilizing BioServe’s genomics services platform, researchers can identify genetic markers, validate drug targets that cause disease and correlate clinical data with molecular data to accelerate the development of new and safer drugs. BioServe’s services extend from nucleic acids processing, DNA synthesis, high throughput sequencing and genotyping, genome wide-scans and gene expression analyses to ready-made large epidemiologically sound case-control studies of inflammatory disorders, endocrine disorders, cardiovascular disease, diabetes, hypertension, obesity and many cancers. BioServe’s Global Repository® provides researchers with a library of 600,000 human DNA, tissue and serum samples linked to detailed clinical and demographic data from 140,000 consented and anonymized patients from four continents. BioServe’s customers include leading pharmaceutical and biotechnology companies, and government and academic research institutions. BioServe has headquarters in Beltsville, MD and Hyderabad, India. For more information please visit www.bioserve.com or call 301-470-3362.
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