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Enzymes in Drug Discovery Summit February 29 ̵...

We are excited to announce the Enzymes in Drug Discovery Summit, which will take place February 29 – March 2, 2016 in San Diego, CA. Enzymes have proven to be an important group of drug targets in diseases, and enzyme inhibitors have been among the most successful of drugs. Join us as we discuss ways to overcome drug resistance to these inhibitors, and discuss breakthroughs in targeting historically undruggable...

6th Ubiquitin Research & Drug Discovery Confe...

We are pleased to invite you to GTCbio’s 6th Ubiquitin Research & Drug Discovery Conference, which will take place February 29 – March 1, 2016 in San Diego, CA. This conference will provide a forum for researchers from industry and academia to learn about recent advances in basic science and drugs that target the ubiquitin/proteasome system. Hot topics such as autophagy in cancer, developments with...

Stem cells from human body fat used to deliver tre...

Johns Hopkins researchers say they have successfully used stem cells derived from human body fat to deliver biological treatments directly to the brains of mice with the most common and aggressive form of brain tumor, significantly extending their lives. In the mouse experiments, the Johns Hopkins investigators used mesenchymal stem cells (MSCs) – which have an unexplained ability to seek out cancer and other damaged...

Positing Parkinson’s as an autoimmune diseas...

Parkinson’s disease, like Alzheimer’s disease, is one of the leading neurodegenerative issues being targeted by the biopharmaceutical and life sciences industries today. It is the result of the death of neurons responsible for producing dopamine, which the Parkinson’s Disease Foundation describes as “A chemical messenger that regulates movement by assisting in the effective communication (transmission) of...

High protein levels linked to cell death in Parkin...

Researchers may have discovered how a genetic mechanism in a common cause of Parkinson’s works to destroy brain cells in patients–a finding that could help scientists develop new therapies for the devastating disease. Though most causes of Parkinson’s cases are unknown, mutations in a gene called leucine-rich repeat kinase 2–or LRRK2, pronounced “lark two” or “lurk...

Stabilizing protein complex in brain offers hope f...

A team of investigators has identified a new class of compounds that could work in a specific protein complex in the brain to provide a safe route toward reversing the devastating symptoms of Alzheimer’s. Known as the retromer protein complex, these proteins are found in reduced levels in the brains of Alzheimer’s patients. Retromers play a crucial role in neurons, steering amyloid precursor protein away from a...
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