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Stabilizing protein complex in brain offers hope f...

A team of investigators has identified a new class of compounds that could work in a specific protein complex in the brain to provide a safe route toward reversing the devastating symptoms of Alzheimer’s. Known as the retromer protein complex, these proteins are found in reduced levels in the brains of Alzheimer’s patients. Retromers play a crucial role in neurons, steering amyloid precursor protein away from a...

Illuminate key structure in heart cells

After a decade of debate, scientists have a clear picture of a controversial protein that helps regulate heart contractions. Brandeis University researchers have unlocked a controversial structure in heart cells responsible for regulating heart contractions. For years, scientists have debated how many KCNE1 proteins are required to build a potassium ion channel, theorizing anywhere between one and 14. Now, Brandeis University...

Adaptor protein role in diabetes, cancer treatment...

A protein known to be part of a complex communications network within the cell has also been found to be associated with important processes involved in cancer and diabetes. In a study that will be published Feb. 18 in Science Signaling, researchers identified a new role for the adaptor protein p66Shc in controlling glucose metabolism and cell growth, two processes that are highly regulated in our cells. When disruptions in...

Imaging technique captures the vibrations of prote...

Like the strings on a violin or the pipes of an organ, the proteins in the human body vibrate in different patterns, scientists have long suspected. Now, a new study provides what researchers say is the first conclusive evidence that this is true. Using a technique they developed based on terahertz near-field microscopy, scientists from the University at Buffalo and Hauptman-Woodward Medical Research Institute (HWI) have for...

Potential drug targets for early onset glaucoma

Using a novel high-throughput screening process, scientists have for the first time identified molecules with the potential to block the accumulation of a toxic eye protein that can lead to early onset of glaucoma. Glaucoma is a group of diseases that can damage the eye’s optic nerve and cause vision loss and blindness. Elevated eye pressure is the main risk factor for optic nerve damage. Researchers have implicated a...

Phosphorylation: over 140 phosphospecific antibodi...

Phosphorylation plays critical roles in the regulation of many cellular processes. It is tightly associated with protein activity and is a key point of protein function regulation. Phosphorylation is the attachment of a phosphate group to a protein or other organic molecule. Once the new phosphate group is added by protein phosphorylation, it changes the structure of its host protein. The new phosphorus group alters the role...
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